Bianco S, Robuschi M, Ceserani R, Gandolfi C
Eur J Respir Dis Suppl. 1980;106:81-7.
The efficacy of prostacyclin in preventing aspecifically and specifically induced bronchoconstriction was evaluated in a single-blind cross-over study in 3 groups of asthmatic patients. Prostacyclin was given by inhalation in doses of 250 microgram in women and 500 microgram in men. Ultrasonic mist of H2O (group 1), physical exercise on cycloergometer (group 2) and pneumoallergens (group 3) were used as bronchial stimulant agents. Prostacyclin gave a very good protection in the first 2 groups, but was ineffective in the third. An increase in heart rate was observed immediately after the inhalation of prostacyclin: this effect was particularly evident in women in whom a significant decrease in diastolic pressure was noted too.
在一项针对三组哮喘患者的单盲交叉研究中，评估了前列环素预防非特异性和特异性诱导的支气管收缩的疗效。前列环素通过吸入给药，女性剂量为250微克，男性剂量为500微克。使用H2O超声雾化（第1组）、在自行车测力计上进行体育锻炼（第2组）和吸入变应原（第3组）作为支气管刺激剂。前列环素在前两组中提供了很好的保护作用，但在第三组中无效。吸入前列环素后立即观察到心率增加：这种效应在女性中尤为明显，同时还观察到舒张压显著下降。
