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前列环素对哮喘患者抗原诱导的速发型支气管收缩的影响。

Effect of prostacyclin on antigen induced immediate bronchoconstriction in asthmatic patients.

作者信息

Bianco S, Robuschi M, Grugni A, Ceserani R, Gandolfi C

出版信息

Prostaglandins Med. 1979 Jul;3(1):39-45. doi: 10.1016/0161-4630(79)90014-4.

DOI:10.1016/0161-4630(79)90014-4
PMID:399527
Abstract

The effect of premedication with inhaled prostacyclin (PGI2) on the allergen induced immediate bronchoconstriction was investigated in 10 asthmatic patients, under single blind conditions, by means of a body plethysmograph. Statistical analysis (Dunnett's test) did not show any significant difference between PGI2 and placebo. The possible meaning of these results is discussed.

摘要

在10名哮喘患者中,采用体容积描记法,在单盲条件下研究了吸入前列环素(PGI2)预处理对变应原诱发的速发型支气管收缩的影响。统计分析(Dunnett检验)显示PGI2与安慰剂之间无显著差异。并对这些结果的可能意义进行了讨论。

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The role of prostaglandins in allergic lung inflammation and asthma.前列腺素在过敏性肺部炎症和哮喘中的作用。
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In vivo allergen tachyphylaxis in guinea pig lung is mediated by endogenous prostaglandin E biosynthesis.豚鼠肺内的体内变应原快速脱敏是由内源性前列腺素E生物合成介导的。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):275-82. doi: 10.1007/BF00495955.
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Sequential histamine inhalations cause increased bronchial histamine reactivity in guinea pigs: role of platelets, thromboxanes and prostacyclin.连续吸入组胺会导致豚鼠支气管组胺反应性增加:血小板、血栓素和前列环素的作用。
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