人体对咖啡因体液和血流动力学效应的耐受性。
Tolerance to the humoral and hemodynamic effects of caffeine in man.
作者信息
Robertson D, Wade D, Workman R, Woosley R L, Oates J A
出版信息
J Clin Invest. 1981 Apr;67(4):1111-7. doi: 10.1172/jci110124.
Abstract
Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines. Using a double-blind design, the effects of chronic caffeine administration on these same variables were assessed. Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine. No long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines could be demonstrated. Discontinuation of caffeine ingestion after 7 d of administration did not result in a detectable withdrawal phenomenon relating to any of the variables assessed.
摘要
在通常不摄入甲基黄嘌呤的受试者中，急性摄入咖啡因会导致血压、心率、血浆肾上腺素、血浆去甲肾上腺素、血浆肾素活性和尿儿茶酚胺升高。采用双盲设计，评估了长期给予咖啡因对这些相同变量的影响。在咖啡因摄入的前1 - 4天，就体液和血流动力学变量而言，几乎完全产生了耐受性。未发现咖啡因对血压、心率、血浆肾素活性、血浆儿茶酚胺或尿儿茶酚胺有长期影响。给予咖啡因7天后停止摄入，未出现与所评估的任何变量相关的可检测到的戒断现象。
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