Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Golgi Cenci Foundation, Abbiategrasso (Milan), Italy.
J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2081-2089. doi: 10.1093/gerona/glab244.
Frailty syndrome is an age-related condition involving a loss of resilience, susceptibility to adverse health outcomes, and poor quality of life. This study was conducted in the framework of InveCe.Ab, an ongoing longitudinal population-based study. Plasma from 130 older individuals (older adults aged 76-78 years) was analyzed and validated (on 303 participants) using mass spectrometry-based metabolomics approaches. Equivalence tests showed that metabolites from the central cellular metabolic pathways were equivalent in frail and fit participants. Hippuric acid was the only cometabolite that distinguished fit from frail older adults. Logistic regression analysis indicated that high hippuric acid levels are significantly associated with a reduction of the risk of frailty after 4 years. Mediation analysis using a Frailty Index, hippuric acid, and fruit-vegetable intake supported the role of fruit-vegetable consumption in the hippuric acid relationship with the Frailty Index. These data point to low plasma hippuric acid as a plausible hallmark of frailty status, associated with lower fruit-vegetable intakes.
衰弱综合征是一种与年龄相关的病症，涉及到身体的弹性丧失、易患不良健康后果和生活质量下降。本研究是在 InveCe.Ab 这一正在进行的基于人群的纵向研究框架内进行的。使用基于质谱的代谢组学方法分析并验证了 130 名老年人（76-78 岁的老年人）的血浆。等效性检验表明，衰弱和健康参与者的中央细胞代谢途径的代谢物是等效的。马尿酸是唯一能够区分健康和衰弱老年人的共生代谢物。逻辑回归分析表明，高马尿酸水平与 4 年后衰弱风险降低显著相关。使用衰弱指数、马尿酸和水果-蔬菜摄入量进行的中介分析支持了水果-蔬菜摄入量在马尿酸与衰弱指数关系中的作用。这些数据表明，血浆中马尿酸水平较低可能是衰弱状态的一个合理标志，与较低的水果-蔬菜摄入量有关。
