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耳蜗毛细胞中的细胞骨架和类肌肉成分。

Cytoskeletal and muscle-like elements in cochlear hair cells.

作者信息

Zenner H P

出版信息

Arch Otorhinolaryngol. 1981;230(1):81-92. doi: 10.1007/BF00665383.

DOI:10.1007/BF00665383
PMID:7011285
Abstract

Monospecific antibodies to actin and to tubulin were used as immunofluorescent probes to evaluate the distribution of microtubules and actin filaments in the organ of Corti in mouse and guinea pig. The results indicate that in cochlear receptor cells actin and actin filaments as well as tubulin and microtubules are integral cytoskeletal elements. The presence of actin suggests a possible contractile mechanism within the sensory cilia whereas tubulin is thought to play an important role in the stability of sensory cells. Both proteins are discussed to form structural elements required for the mechano-chemical coupling in hearing.

摘要

抗肌动蛋白和抗微管蛋白的单特异性抗体被用作免疫荧光探针，以评估小鼠和豚鼠柯蒂氏器中微管和肌动蛋白丝的分布。结果表明，在耳蜗受体细胞中，肌动蛋白和肌动蛋白丝以及微管蛋白和微管是完整的细胞骨架成分。肌动蛋白的存在表明感觉纤毛内可能存在收缩机制，而微管蛋白被认为在感觉细胞的稳定性中起重要作用。讨论了这两种蛋白质形成听力中机械化学偶联所需的结构元件。

相似文献

1
Cytoskeletal and muscle-like elements in cochlear hair cells.耳蜗毛细胞中的细胞骨架和类肌肉成分。
Arch Otorhinolaryngol. 1981;230(1):81-92. doi: 10.1007/BF00665383.
2
Immunohistochemical localization of several cytoskeletal proteins in inner ear sensory and supporting cells.几种细胞骨架蛋白在内耳感觉细胞和支持细胞中的免疫组织化学定位。
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3
Actin-binding and microtubule-associated proteins in the organ of Corti.柯蒂氏器中的肌动蛋白结合蛋白和微管相关蛋白。
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Tropomyosin co-localizes with actin microfilaments and microtubules within supporting cells of the inner ear.原肌球蛋白与内耳支持细胞内的肌动蛋白微丝和微管共定位。
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Expression of actin isoforms in the guinea pig organ of Corti: muscle isoforms are not detected.
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The arrangements of F-actin, tubulin and fodrin in the organ of Corti of the horseshoe bat (Rhinolophus rouxi) and the gerbil (Meriones unguiculatus).菊头蝠（鲁氏菊头蝠）和长爪沙鼠的柯蒂氏器中F-肌动蛋白、微管蛋白和血影蛋白的排列
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F-actin, tubulin and spectrin in the organ of Corti: comparative distribution in different cell types and mammalian species.耳蜗中的丝状肌动蛋白、微管蛋白和血影蛋白：在不同细胞类型和哺乳动物物种中的比较分布
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Organization of microtubules in cochlear hair cells.耳蜗毛细胞中微管的组织
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Distribution of cytoskeletal elements in cultured skin fibroblasts of patients with Duchenne's muscular dystrophy.
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引用本文的文献

1
Immunofluorescence localizations of proteins in semithin 0.2--1 micron frozen sections of the ear. A report of improved techniques including gelatin encapsulation and cryoultramicrotomy.耳部0.2 - 1微米半薄冰冻切片中蛋白质的免疫荧光定位。关于包括明胶包封和冷冻超薄切片术在内的改进技术的报告。
Arch Otorhinolaryngol. 1981;233(1):55-66. doi: 10.1007/BF00464275.
2
Immunocytochemical detection of calcium-binding protein in the cochlear and vestibular hair cells of the rat.大鼠耳蜗和前庭毛细胞中钙结合蛋白的免疫细胞化学检测
Cell Tissue Res. 1983;232(3):691-6. doi: 10.1007/BF00216440.
3
Inhibition of myosin light-chain kinase activity in the organ of Corti by 0.3-5 kilodalton substances of the otosclerotic perilymph.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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CYTOARCHITECTURE OF THE ORGAN OF CORTI.
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Tropomyosin co-localizes with actin microfilaments and microtubules within supporting cells of the inner ear.原肌球蛋白与内耳支持细胞内的肌动蛋白微丝和微管共定位。
Cell Tissue Res. 1987 Apr;248(1):63-6. doi: 10.1007/BF01239963.
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Correlative immuno-electron-microscopic and immunofluorescent localization of actin in sensory and supporting cells of the inner ear by use of a low-temperature embedding resin.利用低温包埋树脂对内耳感觉细胞和支持细胞中肌动蛋白进行免疫电子显微镜和免疫荧光相关定位。
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Outer hair cell electromotility and otoacoustic emissions.外毛细胞电运动与耳声发射。
Ear Hear. 1990 Apr;11(2):82-92. doi: 10.1097/00003446-199004000-00003.
4
Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability.鬼笔环肽诱导的胆汁淤积：微丝介导的连接复合体通透性变化
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2229-33. doi: 10.1073/pnas.77.4.2229.
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The organization of actin filaments in the stereocilia of cochlear hair cells.耳蜗毛细胞静纤毛中肌动蛋白丝的组织
J Cell Biol. 1980 Jul;86(1):244-59. doi: 10.1083/jcb.86.1.244.
6
Brownian motion in the cochlear partition.耳蜗隔板中的布朗运动。
J Acoust Soc Am. 1968 Jul;44(1):176-86. doi: 10.1121/1.1911052.
7
Selective enzyme purification by affinity chromatography.通过亲和色谱法进行选择性酶纯化。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):636-43. doi: 10.1073/pnas.61.2.636.
8
Microtubules.微管
Annu Rev Biochem. 1973;42:507-40. doi: 10.1146/annurev.bi.42.070173.002451.
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[Hair cell damage pattern following parenteral gentamicin administration in guinea pigs].
Z Laryngol Rhinol Otol. 1972 Dec;51(12):845-66.
10
Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A.伴刀豆球蛋白A对淋巴细胞免疫球蛋白受体流动性的限制
Proc Natl Acad Sci U S A. 1972 Mar;69(3):608-12. doi: 10.1073/pnas.69.3.608.