迟发型超敏反应与宿主对查巴迪疟原虫感染的抵抗力之间缺乏相关性。
Lack of correlation between delayed-type hypersensitivity and host resistance to Plasmodium chabaudi infection.
作者信息
McDonald V, Sherman I W
出版信息
Clin Exp Immunol. 1980 Dec;42(3):421-7.
C57B1/6J mice immunized with Plasmodium chabaudi antigen plus saponin exhibited strong delayed-type hypersensitivity (DTH) reactions to footpad injections of P. chabaudi antigen. However, when immunized mice were challenged with P. chabaudi parasites, DTH was significantly depressed after 3 days of infection. This DTH depression coincided with a steep rise in the titre of malarial antibody in these immunized challenged mice when compared to unchallenged immunized mice. Serum from mice recovering from P. chabaudi infection depressed DTH levels of immunized mice significantly, but spleen cells from convalescent mice only slightly reduced the DTH levels. These results are discussed with respect to the role of cell-mediated immunity in malaria infections.
用查巴迪疟原虫抗原加皂苷免疫的C57B1/6J小鼠，对足垫注射查巴迪疟原虫抗原表现出强烈的迟发型超敏反应（DTH）。然而，当用查巴迪疟原虫寄生虫攻击免疫小鼠时，感染3天后DTH明显降低。与未受攻击的免疫小鼠相比，这种DTH降低与这些受攻击的免疫小鼠中疟疾抗体滴度的急剧上升相吻合。从查巴迪疟原虫感染中恢复的小鼠血清显著降低了免疫小鼠的DTH水平，但恢复期小鼠的脾细胞仅略微降低了DTH水平。针对细胞介导免疫在疟疾感染中的作用对这些结果进行了讨论。
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