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1
Lack of correlation between delayed-type hypersensitivity and host resistance to Plasmodium chabaudi infection.迟发型超敏反应与宿主对查巴迪疟原虫感染的抵抗力之间缺乏相关性。
Clin Exp Immunol. 1980 Dec;42(3):421-7.
2
Cell-mediated immunity in mice vaccinated against malaria.接种疟疾疫苗的小鼠的细胞介导免疫
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Exp Parasitol. 1980 Jun;49(3):442-54. doi: 10.1016/0014-4894(80)90078-8.
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Protective immunity to malaria: studies with cloned lines of Plasmodium chabaudi chabaudi in CBA/Ca mice. III. Protective and suppressive responses induced by immunization with purified antigens.疟疾的保护性免疫：对CBA/Ca小鼠体内的沙氏疟原虫克隆株的研究。III. 纯化抗原免疫诱导的保护性和抑制性反应。
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Ann Trop Med Parasitol. 1983 Aug;77(4):355-77. doi: 10.1080/00034983.1983.11811724.
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8
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The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. I. Spleen dendritic cells.抗原呈递细胞在迟发型超敏反应调节中的作用。I. 脾脏树突状细胞。
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引用本文的文献

1
Relationship between delayed hypersensitivity response and acquired cell-mediated immunity in C57BL/6J mice infected with Leishmania donovani.杜氏利什曼原虫感染的C57BL/6J小鼠中迟发型超敏反应与获得性细胞介导免疫之间的关系
Infect Immun. 1985 Aug;49(2):447-51. doi: 10.1128/iai.49.2.447-451.1985.

本文引用的文献

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Gamma-globulin and acquired immunity to human malaria.γ-球蛋白与人类疟疾的获得性免疫
Nature. 1961 Nov 25;192:733-7. doi: 10.1038/192733a0.
2
Plasmodium chabaudi: humoral and cell-mediated responses of immunized mice.查巴迪疟原虫：免疫小鼠的体液和细胞介导反应
Exp Parasitol. 1980 Jun;49(3):442-54. doi: 10.1016/0014-4894(80)90078-8.
3
Plasmodium chabaudi: adoptive transfer of immunity with different spleen cell populations and development of protective activity in the serum of lethally irradiated recipient mice.查巴迪疟原虫：不同脾细胞群体免疫的过继转移及致死剂量照射受体小鼠血清中保护活性的发展
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Plasmodium berghei infections in thymectomized rats.切除胸腺的大鼠感染伯氏疟原虫
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Immunity to malaria. 3. Possible occurrence of a cell-mediated immunity to Plasmodium knowlesi in chronically infected and Freund's complete adjuvant-sensitized monkeys.对疟疾的免疫力。3. 慢性感染且经弗氏完全佐剂致敏的猴子中可能存在对诺氏疟原虫的细胞介导免疫。
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The relationship of delayed hypersensitivity to acquired antituberculous immunity. I. Tuberculin sensitivity and resistance to reinfection in BCG-vaccinated mice.迟发型超敏反应与获得性抗结核免疫的关系。I. 卡介苗接种小鼠的结核菌素敏感性及对再感染的抵抗力
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Immunofluorescence method suitable for large-scale application to malaria.适用于大规模疟疾检测的免疫荧光法。
Bull World Health Organ. 1971;45(4):524-9.
8
Murine malaria. IV. Disturbed immunological responsiveness during Plasmodium berghei infection.鼠疟。IV. 伯氏疟原虫感染期间免疫反应紊乱。
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9
Feedback inhibition of specifically sensitized lymphocytes.特异性致敏淋巴细胞的反馈抑制
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10
Further studies on B-lymphocyte suppression in delayed hypersensitivity, indicating a possible mechanism for Jones-Mote hypersensitivity.对迟发型超敏反应中B淋巴细胞抑制作用的进一步研究，揭示了琼斯-莫特超敏反应的一种可能机制。
Immunology. 1973 Apr;24(4):751-8.

迟发型超敏反应与宿主对查巴迪疟原虫感染的抵抗力之间缺乏相关性。

Lack of correlation between delayed-type hypersensitivity and host resistance to Plasmodium chabaudi infection.

作者信息

McDonald V, Sherman I W

出版信息

Clin Exp Immunol. 1980 Dec;42(3):421-7.

PMID:7011608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537167/
Abstract

C57B1/6J mice immunized with Plasmodium chabaudi antigen plus saponin exhibited strong delayed-type hypersensitivity (DTH) reactions to footpad injections of P. chabaudi antigen. However, when immunized mice were challenged with P. chabaudi parasites, DTH was significantly depressed after 3 days of infection. This DTH depression coincided with a steep rise in the titre of malarial antibody in these immunized challenged mice when compared to unchallenged immunized mice. Serum from mice recovering from P. chabaudi infection depressed DTH levels of immunized mice significantly, but spleen cells from convalescent mice only slightly reduced the DTH levels. These results are discussed with respect to the role of cell-mediated immunity in malaria infections.

摘要

用查巴迪疟原虫抗原加皂苷免疫的C57B1/6J小鼠，对足垫注射查巴迪疟原虫抗原表现出强烈的迟发型超敏反应（DTH）。然而，当用查巴迪疟原虫寄生虫攻击免疫小鼠时，感染3天后DTH明显降低。与未受攻击的免疫小鼠相比，这种DTH降低与这些受攻击的免疫小鼠中疟疾抗体滴度的急剧上升相吻合。从查巴迪疟原虫感染中恢复的小鼠血清显著降低了免疫小鼠的DTH水平，但恢复期小鼠的脾细胞仅略微降低了DTH水平。针对细胞介导免疫在疟疾感染中的作用对这些结果进行了讨论。