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来自巴布亚新几内亚的恶性疟原虫菌株:培养特性与药物敏感性。

Plasmodium falciparum strains from Papua New Guinea: culture characteristics and drug sensitivity.

作者信息

Chen P, Lamont G, Elliott T, Kidson C, Brown G, Mitchell G, Stace J, Alpers M

出版信息

Southeast Asian J Trop Med Public Health. 1980 Dec;11(4):435-40.

PMID:7013092
Abstract

Seven strains of Plasmodium falciparum from Papua New Guinea have been established in continuous in vitro culture. Samples with a high initial parasitaemia were more likely to form continuous lines, possibly due to the time required for transport of infected blood samples from Papua New Guinea to laboratories in Australia. Most but not all established lines were resistant to chloroquine and all were resistant to pyrimethamine, possibly reflecting the parasite strain characteristics in that region.

摘要

来自巴布亚新几内亚的七株恶性疟原虫已在体外连续培养。初始寄生虫血症水平高的样本更有可能形成连续传代系,这可能是由于感染血液样本从巴布亚新几内亚运输到澳大利亚实验室所需的时间。大多数(但并非全部)已建立的传代系对氯喹耐药,且全部对乙胺嘧啶耐药,这可能反映了该地区寄生虫菌株的特征。

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