Kjaernes M, Svindland A, Walløe L, Wille S O
Acta Pathol Microbiol Scand A. 1981 Jan;89(1):35-40. doi: 10.1111/j.1699-0463.1981.tb00184.x.
The detailed localization of early atherosclerotic lesions in arterial bifurcations was studied in 33 brachiocephalic arteries obtained from autopsies of young persons who had suffered a violent and sudden death. Drawings of the sudanophilic lesions in the vessel wall were fed to a computer, scaled to a standardized size and shape, and added together. The results are presented as contour lines connecting points with equal frequency of early lesions. The distribution of the early lesions reveals a distinct pattern: The early lesions start to develop on the outer walls of the bifurcation, while the inner walls downstream from the flow divider are kept free as are also the lateral walls. These results are clearly in conflict with Fry's shear stress hypothesis, while they seem to support Caro's hypothesis of inhibition of local diffusionsal transport. The results are also at variance with results obtained in most animal models, suggesting that the process which takes place in the vessel wall in these animals may be different from human atherosclerosis.
对33条取自因暴力猝死的年轻人尸检的头臂动脉进行研究，以明确早期动脉粥样硬化病变在动脉分叉处的详细定位。将血管壁上嗜苏丹性病变的绘图输入计算机，按标准化大小和形状进行缩放，然后叠加在一起。结果以连接早期病变频率相等的点的等高线呈现。早期病变的分布呈现出一种独特模式：早期病变开始于分叉处的外壁，而分流器下游的内壁以及侧壁均未出现病变。这些结果显然与弗莱的剪切应力假说相矛盾，而似乎支持卡罗的局部扩散转运抑制假说。这些结果也与大多数动物模型中获得的结果不一致，表明这些动物血管壁中发生的过程可能与人类动脉粥样硬化不同。
