Sakata N, Joshita T, Ooneda G
Heart Vessels. 1985 May;1(2):70-3. doi: 10.1007/BF02066351.
We have studied the topographical distribution of arteriosclerotic lesions at the bifurcation of the internal carotid-anterior cerebral-middle cerebral arteries (internal carotid bifurcation) and of the middle cerebral artery-first temporal branch (first bifurcation of M.C.A.) in humans. The arteriosclerotic lesions showed a distinct pattern with a high incidence on the outer walls of the daughter vessels and at the inner curvatures in the bifurcations where wall shear stress was believed to be relatively low. However, there were differences in the distribution of the lesions between the internal carotid bifurcations and the first bifurcations of M.C.A.. The former are considered to be three-dimensionally unsymmetrical and curved, and the latter symmetrical and straight. The present study suggests that lower shear stress is of considerable importance in both the initiation and localization of arteriosclerotic lesions, and that study of the three-dimensional blood vessel architecture and blood flow patterns needs to be done to clarify the role of hemodynamic forces in atherogenesis.
我们研究了人类颈内动脉-大脑前动脉-大脑中动脉分叉处（颈内动脉分叉）以及大脑中动脉-第一颞支分叉处（大脑中动脉第一分叉）动脉粥样硬化病变的地形分布。动脉粥样硬化病变呈现出一种独特的模式，在分支血管的外壁以及分叉处的内曲率处发生率较高，据信此处的壁面剪应力相对较低。然而，颈内动脉分叉处和大脑中动脉第一分叉处的病变分布存在差异。前者被认为是三维不对称且弯曲的，而后者是对称且笔直的。本研究表明，较低的剪应力在动脉粥样硬化病变的起始和定位中都相当重要，并且需要研究三维血管结构和血流模式以阐明血流动力学力在动脉粥样硬化形成中的作用。
