Graf R J, Halter J B, Pfeifer M A, Halar E, Brozovich F, Porte D
Ann Intern Med. 1981 Mar;94(3):307-11. doi: 10.7326/0003-4819-94-3-307.
The influence of therapy of hyperglycemia on the progression of diabetic neuropathy is unclear. We studied variables of glycemia and motor and sensory nerve conduction velocity in a group of 18 non-insulin-dependent diabetic subjects before and after institution of diabetes therapy. Diabetes therapy significantly reduced variables of glycemia after 1, 3, 6, and 12 months. Conduction velocity of the median motor nerve was improved from baseline at each time tested during treatment. In addition, peroneal and tibial motor nerve conduction velocities improved in patients whose levels of hyperglycemia were lowered. Moreover, extent of improvement of conduction velocity of some motor nerves was related to the degree of reduction of hyperglycemia. Sensory nerve conduction velocity was not altered by diabetes therapy. These findings support the hypothesis of a metabolic component to diabetic neuropathy and suggest that optimal glycemic control may be beneficial to patients with this disorder.
高血糖治疗对糖尿病神经病变进展的影响尚不清楚。我们在一组18名非胰岛素依赖型糖尿病患者开始糖尿病治疗前后，研究了血糖变量以及运动和感觉神经传导速度。糖尿病治疗在1、3、6和12个月后显著降低了血糖变量。在治疗期间每次测试时，正中运动神经的传导速度均较基线有所改善。此外，高血糖水平降低的患者腓总神经和胫神经运动神经传导速度也有所改善。而且，一些运动神经传导速度的改善程度与高血糖降低的程度有关。糖尿病治疗未改变感觉神经传导速度。这些发现支持了糖尿病神经病变存在代谢成分的假说，并表明最佳血糖控制可能对患有这种疾病的患者有益。
