Thomsen J, Bretlau P, Tos M, Johnsen N J
Arch Otolaryngol. 1981 May;107(5):271-7. doi: 10.1001/archotol.1981.00790410009002.
To investigate the placebo effect in surgery for Ménière's disease, a double-blind controlled study was undertaken, comparing effects of a regular endolymphatic shunt with those of regular mastoidectomy. Thirty patients with typical Ménière's diseases, selected because of unsuccessful medical treatment, participated. Patients completed daily dizziness questionnaires three months before and 12 months after surgery, with registration of nausea, vomiting, vertigo, tinnitus, hearing impairment, and pressure in the ears. Patients were operated on at two universities, and the patients operated on at one underwent controlled study each month at the other. At termination of the trial, both investigators and patients gave their opinions of the efficacy of the operations. Minor differences were seen between active and placebo groups, but the greatest difference in symptoms was found when preoperative and postoperative scores were compared: both groups improved significantly
为研究梅尼埃病手术中的安慰剂效应，开展了一项双盲对照研究，比较常规内淋巴囊分流术与常规乳突切除术的效果。选取了30例因药物治疗无效而入选的典型梅尼埃病患者。患者在手术前三个月和手术后12个月每天填写头晕问卷，记录恶心、呕吐、眩晕、耳鸣、听力障碍和耳内压力情况。患者在两所大学接受手术，在其中一所大学接受手术的患者每月在另一所大学接受对照研究。试验结束时，研究者和患者都对手术效果发表了意见。活性组和安慰剂组之间存在细微差异，但比较术前和术后评分时发现症状差异最大：两组均有显著改善
