Goldman J K, MacKenzie R, Bernardis L L, Luboshitzky R, Kodis M
Metabolism. 1980 Oct;29(11):1061-4. doi: 10.1016/0026-0495(80)90217-6.
Studies were performed to determine whether increased gluconeogenesis precedes or is necessary for increased lipogenesis after ventromedial hypothalamic destruction. Weanling male rats were injected with 14C-bicarbonate or with 3H2O to assess gluconeogenesis or lipogenesis, respectively, at various short time intervals after placement of hypothalamic lesions. Lipogenesis increased within 2 hr of lesion placement whereas gluconeogenesis did not change for at least 4 hr. The results indicate that lipogenesis increases before gluconeogenesis and, therefore, that enhanced glucose production is not necessary for increased lipogenesis to occur in these rats.
进行了多项研究，以确定在腹内侧下丘脑损毁后，糖异生增加是先于脂肪生成增加还是对其增加是必需的。给断奶雄性大鼠注射14C-碳酸氢盐或3H2O，分别在放置下丘脑损伤后的不同短时间间隔评估糖异生或脂肪生成。损伤放置后2小时内脂肪生成增加，而糖异生至少4小时未发生变化。结果表明，在这些大鼠中，脂肪生成在糖异生前增加，因此，增加脂肪生成并不一定需要增强葡萄糖生成。
