梅毒螺旋体将葡萄糖掺入大分子物质中的分布情况。
Distribution of glucose incorporated into macromolecular material by treponema pallidum.
作者信息
Barbieri J T, Austin F E, Cox C D
出版信息
Infect Immun. 1981 Mar;31(3):1071-7. doi: 10.1128/iai.31.3.1071-1077.1981.
Abstract
Treponema pallidum was observed to incorporate glucose carbons into lipids, ribonucleic acid, deoxyribonucleic acid, and protein. Only the glycerol portions of phosphatidylcholine and phosphatidylglycerol contained glucose-derived carbons. Incorporation of exogenous choline into phosphatidylcholine was detected. Glucose was incorporated into only the pentoses of nucleic acids. About 50% of the glucose incorporated into protein was present in only one amino acid, aspartate. Evidence suggests that aspartate synthesis could follow the conversion of phosphoenolpyruvate to oxalacetic acid by a guanosine 5'-diphosphate-dependent phosphoenolpyruvate carboxykinase.
摘要
观察到梅毒螺旋体可将葡萄糖碳掺入脂质、核糖核酸、脱氧核糖核酸和蛋白质中。仅磷脂酰胆碱和磷脂酰甘油的甘油部分含有葡萄糖衍生的碳。检测到外源胆碱掺入磷脂酰胆碱中。葡萄糖仅掺入核酸的戊糖中。掺入蛋白质中的葡萄糖约50%仅存在于一种氨基酸即天冬氨酸中。有证据表明，天冬氨酸的合成可能通过鸟苷5'-二磷酸依赖性磷酸烯醇丙酮酸羧激酶将磷酸烯醇丙酮酸转化为草酰乙酸之后进行。
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