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关于泛醌在线粒体呼吸链中作用的新概念。

New concepts on the role of ubiquinone in the mitochondrial respiratory chain.

作者信息

Trumpower B L

出版信息

J Bioenerg Biomembr. 1981 Apr;13(1-2):1-24. doi: 10.1007/BF00744743.

DOI:10.1007/BF00744743
PMID:7014553
Abstract

Ubiquinone participates in the oxidation-reduction reactions of the mitochondrial respiratory chain. In addition, this molecule possesses the necessary properties to function as a hydrogen carrier, thereby stoichiometrically coupling proton translocation to respiration by a direct chemiosmotic mechanism. This review discusses recent experimental evidence and new concepts relating to ubiquinone function in the mitochondrial respiratory chain. Emphasis is placed on possible protonmotive mechanisms of ubiquinone function, recent evidence implicating stable forms of ubisemiquinone in the respiratory chain, and properties of the ubiquinone molecule which may relate to its biological function.

摘要

泛醌参与线粒体呼吸链的氧化还原反应。此外，该分子具有作为氢载体发挥作用的必要特性，从而通过直接化学渗透机制将质子转运与呼吸作用化学计量地偶联起来。本综述讨论了与泛醌在线粒体呼吸链中的功能相关的最新实验证据和新概念。重点在于泛醌功能可能的质子动力机制、近期表明呼吸链中存在稳定形式的泛半醌的证据，以及可能与其生物学功能相关的泛醌分子特性。

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本文引用的文献

1
On the mechanism of electron transfer in complex iii of the electron transfer chain.关于电子传递链复合物III中电子传递的机制。
Proc Natl Acad Sci U S A. 1967 Mar;57(3):798-805. doi: 10.1073/pnas.57.3.798.
2
The inhibitory effects of quinones on the succinic oxidase system of the respiratory chain.醌类物质对呼吸链琥珀酸氧化酶系统的抑制作用。
Biochim Biophys Acta. 1962 Jan 29;56:440-4. doi: 10.1016/0006-3002(62)90595-4.
3
STUDIES ON THE ELECTRON TRANSFER SYSTEM. 58. PROPERTIES OF A NEW OXIDATION-REDUCTION COMPONENT OF THE RESPIRATORY CHAIN AS STUDIED BY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY.
J Pestic Sci. 2022 Nov 20;47(4):190-196. doi: 10.1584/jpestics.D22-027.
4
Chemistry of Lipoquinones: Properties, Synthesis, and Membrane Location of Ubiquinones, Plastoquinones, and Menaquinones.脂醌的化学：泛醌、质体醌和甲萘醌的性质、合成和膜定位。
Int J Mol Sci. 2022 Oct 25;23(21):12856. doi: 10.3390/ijms232112856.
5
Electron Transport Lipids Fold Within Membrane-Like Interfaces.电子传递脂质在类膜界面内折叠。
Front Chem. 2022 Mar 8;10:827530. doi: 10.3389/fchem.2022.827530. eCollection 2022.
6
Coenzyme Q10 effects in neurological diseases.辅酶 Q10 在神经疾病中的作用。
Physiol Res. 2021 Dec 30;70(Suppl4):S683-S714. doi: 10.33549/physiolres.934712.
7
Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.III 型 ATP 合酶是一种对称性偏离的二聚体，通过四聚化诱导膜弯曲。
Nat Commun. 2020 Oct 22;11(1):5342. doi: 10.1038/s41467-020-18993-6.
8
Identification of Ubiquinones in Honey: A New View on Their Potential Contribution to Honey's Antioxidant State.鉴定蜂蜜中的泛醌：对其潜在贡献于蜂蜜抗氧化状态的新认识。
Molecules. 2018 Nov 23;23(12):3067. doi: 10.3390/molecules23123067.
9
A Comparative Proteome Profile of Female Mouse Gonads Suggests a Tight Link between the Electron Transport Chain and Meiosis Initiation.雌性小鼠性腺的比较蛋白质组谱表明电子传递链与减数分裂起始之间存在紧密联系。
Mol Cell Proteomics. 2018 Jan;17(1):31-42. doi: 10.1074/mcp.M117.066993. Epub 2017 Nov 20.
10
Mechanisms of quinol oxidation in photosynthesis.光合作用中喹诺酮氧化的机制。
Photosynth Res. 1985 Dec;6(4):335-48. doi: 10.1007/BF00054107.
电子传递系统的研究。58. 用电子顺磁共振光谱研究呼吸链新氧化还原成分的性质。
J Biol Chem. 1964 Sep;239:3017-22.
4
Structure and function of subcellular particles.亚细胞颗粒的结构与功能。
Comp Biochem Physiol. 1962 Oct;4:81-122. doi: 10.1016/0010-406x(62)90001-4.
5
The respiratory chain and oxidative phosphorylation.呼吸链与氧化磷酸化。
Adv Enzymol Relat Subj Biochem. 1956;17:65-134. doi: 10.1002/9780470122624.ch2.
6
The H+/O stoicheiometry of mitochondrial respiration.
FEBS Lett. 1980 Feb 25;111(1):243-8. doi: 10.1016/0014-5793(80)80803-9.
7
Inhibition of electron transfer in the cytochrome b-c, segment of the mitochondrial respiratory chain by a synthetic analogue of ubiquinone.泛醌合成类似物对线粒体呼吸链细胞色素b-c1片段中电子传递的抑制作用。
J Bioenerg Biomembr. 1980 Aug;12(3-4):151-64. doi: 10.1007/BF00744680.
8
The role of the Rieske iron-sulfur center as the electron donor to ferricytochrome c2 in Rhodopseudomonas sphaeroides.在球形红假单胞菌中， Rieske 铁硫中心作为细胞色素 c2 铁离子的电子供体的作用。
Biochim Biophys Acta. 1980 Oct 3;592(3):445-60. doi: 10.1016/0005-2728(80)90091-2.
9
Inhibition of the oxidant--induced reduction of cytochrome b by a synthetic analogue of ubiquinone.
FEBS Lett. 1980 Jun 30;115(2):171-4. doi: 10.1016/0014-5793(80)81160-4.
10
Reconstitution of the iron-sulfur protein responsible for the g = 1.90 electron paramagnetic resonance signal and associated cytochrome c reductase activities to depleted succinate-cytochrome c reductase complex.将负责g = 1.90电子顺磁共振信号及相关细胞色素c还原酶活性的铁硫蛋白重组到耗尽的琥珀酸-细胞色素c还原酶复合物中。
J Biol Chem. 1980 Aug 10;255(15):7487-93.