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微摩尔浓度的钙可刺激大鼠脑突触膜中的蛋白水解作用和谷氨酸结合。

Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes.

作者信息

Baudry M, Bundman M C, Smith E K, Lynch G S

出版信息

Science. 1981 May 22;212(4497):937-8. doi: 10.1126/science.7015504.

DOI:10.1126/science.7015504
PMID:7015504
Abstract

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.

摘要

用低浓度钙孵育皮质突触膜，导致一种高分子量双峰蛋白的量减少，以及谷氨酸的非钠依赖性结合增加。这两种效应均被巯基蛋白酶抑制剂亮肽素阻断。这些结果表明，钙诱导的膜成分蛋白水解作用调节神经元膜中谷氨酸受体的数量。

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