胰腺胰岛和分离的β细胞中5-羟色胺转运的进一步研究。
Further studies on 5-hydroxytryptamine transport in pancreatic islets and isolated beta-cells.
作者信息
Lindström P
出版信息
Br J Pharmacol. 1981 Jun;73(2):385-91. doi: 10.1111/j.1476-5381.1981.tb10433.x.
Abstract
1 The transport mechanism for (3)H-labelled 5-hydroxytryptamine (5-HT) in isolated pancreatic islets of non-inbred ob/ob mice was further characterized.2 Isolated beta-cells accumulated 5-HT to the same degree and with the same Na(+)-dependence as whole islets.3 Imipramine inhibited the uptake in a concentration-dependent way.4 Reserpine did not affect the uptake or efflux rates.5 Glucose stimulation of insulin secretion did not affect the uptake rate.6 It is concluded that the observed islet uptake of [(3)H]-5-HT represents an intracellular accumulation by the beta-cells. Mechanisms at the level of the plasma membrane may be rate-limiting for this process.
摘要
1 对非近交系ob/ob小鼠分离的胰岛中（3）H标记的5-羟色胺（5-HT）的转运机制进行了进一步表征。2 分离的β细胞积累5-HT的程度与整个胰岛相同，且具有相同的钠依赖性。3 丙咪嗪以浓度依赖性方式抑制摄取。4 利血平不影响摄取或流出速率。5 葡萄糖刺激胰岛素分泌不影响摄取速率。6 得出结论，观察到的胰岛对[（3）H]-5-HT的摄取代表β细胞的细胞内积累。质膜水平的机制可能是该过程的限速因素。
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