Zanierato G, Ranghino E, Negri L, Morandini G C
Minerva Med. 1981 Feb 28;72(7):443-9.
A comparative trial conducted on 48 male and 9 female patients suitably selected in terms of indication consisted of a first stage in which a completely random, doubleblind comparison was made between acetylsalicylic acid, guacetisal and guaiacol carbonate (preparations A, B, and C) while in the second stage an association of bromexine, acetylsalicylic acid and codeine phosphate (preparation D) was examined in terms of activity and tolerance in an open trial. Statistical analysis showed the superiority of preparation B with respect to most of the parameters taken into consideration.
对48名男性和9名女性患者进行了一项比较试验,这些患者是根据适应症适当挑选出来的。试验分为两个阶段,第一阶段对乙酰水杨酸、胍乙柳酯和愈创木酚碳酸酯(制剂A、B和C)进行完全随机、双盲比较,而在第二阶段,在开放试验中对氨溴索、乙酰水杨酸和磷酸可待因的组合(制剂D)的活性和耐受性进行了研究。统计分析表明,制剂B在大多数考虑的参数方面具有优越性。