Skaug K, Ulstrup J C, Stray-Pedersen B
Scand J Infect Dis. 1981;13(1):11-5. doi: 10.1080/00365548.1981.11690360.
During the 1974 rubella epidemic in Oslo, paired sera from 7781 pregnant women were examined for rubella-specific IgG antibodies using the single radial haemolysis (SRH) test. 12.4% of the women with seronegative in early pregnancy, with no significant variations between the different age groups. In the seropositive samples, there was a mean decrease in the rubella IgG concentration of about 30% during 22 gestational weeks. 53 seroconversions were found. In addition, 22 primary infections were detected by the demonstration of rubella specific IgM antibodies using an indirect immunofluorescence test. The persistence of the rubella IgM antibodies was examined and a large individual variation was found, from less than 1 month up to 4 months after onset of the disease. The serological techniques, particularly the SRH test, were found to be well suited for mass screening.
在1974年奥斯陆风疹流行期间，使用单向辐射溶血（SRH）试验对7781名孕妇的配对血清进行了风疹特异性IgG抗体检测。妊娠早期血清阴性的妇女占12.4%，不同年龄组之间无显著差异。在血清阳性样本中，妊娠22周期间风疹IgG浓度平均下降约30%。发现了53例血清转化。此外，通过间接免疫荧光试验检测风疹特异性IgM抗体，发现了22例原发性感染。对风疹IgM抗体的持续存在情况进行了检查，发现个体差异很大，从发病后不到1个月到4个月不等。发现血清学技术，尤其是SRH试验，非常适合大规模筛查。
