Casslén B, Ohlsson K
Acta Obstet Gynecol Scand. 1981;60(2):103-7.
Electrophoretic homogeneity of alpha 1-antitrypsin (alpha 1-AT) was studied in the uterine fluid from two groups of normal women; one group was comprised of IUD-users, the other non-users. Alpha 1-AT was found in its free and active form in non-users. In IUD-users, one fraction was complexed by granulocyte elastase and neutral proteinase. The other fraction had the same electrophoretic mobility as the native inhibitor, but was inactive, as determined from trypsin inhibition studies. This may explain the finding of elastase activity together with non-complexed alpha 1-AT in some samples from IUD-users. It is concluded that uterine fluid in IUD-users possess a minimal, if any, proteinase inhibiting potential. Non-inhibited activity of granulocyte proteinases in the uterine cavity may influence hemostasis of the endometrium.
对两组正常女性子宫液中的α1 - 抗胰蛋白酶（α1 - AT）进行了电泳均一性研究；一组为宫内节育器（IUD）使用者，另一组为非使用者。在非使用者的子宫液中发现了游离且具有活性形式的α1 - AT。在IUD使用者中，一部分与粒细胞弹性蛋白酶和中性蛋白酶形成复合物。另一部分具有与天然抑制剂相同的电泳迁移率，但根据胰蛋白酶抑制研究确定其无活性。这可能解释了在一些IUD使用者的样本中发现弹性蛋白酶活性以及未形成复合物的α1 - AT的现象。得出的结论是，IUD使用者的子宫液即使有蛋白酶抑制潜力也极小。子宫腔内粒细胞蛋白酶的未受抑制活性可能会影响子宫内膜的止血。
