Pichard A D, Wiener I, Martinez E, Horowitz S, Patterson R, Meller J, Goldsmith S J, Gorlin R, Herman M V
Am Heart J. 1981 Jul;102(1):30-6. doi: 10.1016/0002-8703(81)90409-9.
The use of myocardial perfusion imaging (MPI) to identify obstructive coronary disease of the left anterior descending coronary artery proximal to the first septal perforator (prox LAD) was studied in 60 patients. Perfusion of the septum and anteroapical areas with thallium-201 injected during exercise was compared to results of coronary arteriography. Septal MPI defect was found in 92.3% of patients with obstruction of the proximal LAD, 27.7% of patients with obstruction of LAD distal to first septal perforator, 0% in patients with obstructions involving right or circumflex arteries, and in 10.5% of patients without coronary disease. Anteroapical MPI defects were found with similar frequency in the three groups with obstructive coronary disease. Septal MPI defect had a sensitivity of 92.3% and specificity of 85.4% in the diagnosis of proximal LAD disease. Normal septal perfusion with thallium-201 virtually excluded proximal LAD disease.
在60例患者中研究了使用心肌灌注成像（MPI）来识别第一间隔支近端左前降支冠状动脉（近端LAD）的阻塞性冠状动脉疾病。将运动期间注射的201铊对间隔和前尖段区域的灌注情况与冠状动脉造影结果进行比较。在近端LAD阻塞的患者中，92.3%发现有间隔MPI缺损；在第一间隔支远端LAD阻塞的患者中，27.7%发现有间隔MPI缺损；在涉及右冠状动脉或回旋支动脉阻塞的患者中，0%发现有间隔MPI缺损；在无冠状动脉疾病的患者中，10.5%发现有间隔MPI缺损。在三组患有阻塞性冠状动脉疾病的患者中，前尖段MPI缺损的出现频率相似。间隔MPI缺损在诊断近端LAD疾病时的敏感性为92.3%，特异性为85.4%。201铊显示间隔灌注正常实际上可排除近端LAD疾病。
