Wood E G, Dillon H C
Am J Obstet Gynecol. 1981 Jul 1;140(5):515-20. doi: 10.1016/0002-9378(81)90226-x.
Bacteriuria in pregnancy was prospectively studied in 569 women, with specific reference to group B streptococcal infection. Forty-six patients (8%) had bacteriuria, including 14 with group B streptococcal infection; group B streptococci (GBS) were exceeded in frequency only by Escherichia coli. Two thirds of the bacteriuric patients remained asymptomatic. The outcome of pregnancy was studied in 41/46 bacteriuric patients, including all those with group B streptococcal infection. Two pregnancies ended in intrauterine fetal death, and one neonate developed group B streptococcal sepsis; all three complications occurred in the 14 women with group B streptococcal bacteriuria. Diabetes mellitus appeared to increase the risk of group B streptococcal bacteriuria. This study revealed that group B streptococcal bacteriuria is more common in pregnancy than was previously suspected and suggests that culture methods to detect GBS should be used in bacteriuria screening programs done in pregnancy. In terms of perinatal infection risk, screening for group B streptococcal bacteriuria at or near the time of delivery may be more meaningful than other group B streptococcal surveillance culture studies.
对569名孕妇的菌尿症进行了前瞻性研究，特别关注B族链球菌感染。46名患者（8%）患有菌尿症，其中14例感染B族链球菌；在感染频率上仅次于大肠杆菌的是B族链球菌（GBS）。三分之二的菌尿症患者没有症状。对46例菌尿症患者中的41例（包括所有感染B族链球菌的患者）的妊娠结局进行了研究。有两例妊娠以宫内胎儿死亡告终，一名新生儿发生了B族链球菌败血症；所有这三种并发症都发生在14例感染B族链球菌菌尿症的女性中。糖尿病似乎会增加感染B族链球菌菌尿症的风险。这项研究表明，B族链球菌菌尿症在孕期比之前认为的更为常见，并建议在孕期进行的菌尿症筛查项目中采用检测GBS的培养方法。就围产期感染风险而言，在分娩时或接近分娩时筛查B族链球菌菌尿症可能比其他B族链球菌监测培养研究更有意义。
