Vahedi-Shahandashti Roya, Kasra-Kermanshahi Rouha, Shokouhfard Maliheh, Ghadam Parinaz, Feizabadi Mohammad Mehdi, Teimourian Shahram
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
Iran J Microbiol. 2017 Dec;9(6):348-355.
, a potentially pathogenic bacterium, benefits from its swarming motility and resistance to antibiotic as two important virulence factors. Inappropriate use of antibiotics often results in drug resistance phenomenon in bacterial population. Use of probiotic bacteria has been recommended as partial replacement. In this study, we investigated the effects of some lactobacilli culture supernatant on swarming, motility and antibiotic resistance of .
Antimicrobial activity of lactobacilli supernatant and susceptibility testing carried out on isolates. Pretreatment effect of lactobacilli culture supernatant on antibiotic - resistance pattern in was determined by comparison of the MIC of bacteria before and after the treatment.
Our results showed that pretreatment with ATCC 4356 supernatant can affect the resistance of strains against ceftriaxone, but it had no effect on the resistance to other antibiotics. Furthermore, culture supernatant of lactobacilli with concentrations greater than 2%, had an effect on the swarming ability of ATCC 13880 and inhibited it.
Probiotic bacteria and their metabolites have the ability to inhibit virulence factors such as antibiotic resistance and swarming motility and can be used as alternatives to antibiotics.
[细菌名称]作为一种潜在的致病菌，其群体运动性和对抗生素的耐药性是两个重要的毒力因子。抗生素的不当使用常常导致细菌群体出现耐药现象。推荐使用益生菌作为部分替代方案。在本研究中，我们调查了一些乳酸杆菌培养上清液对[细菌名称]的群体运动性、运动能力和抗生素耐药性的影响。
对[细菌名称]分离株进行乳酸杆菌上清液的抗菌活性及药敏试验。通过比较处理前后细菌的最低抑菌浓度（MIC），确定乳酸杆菌培养上清液对[细菌名称]抗生素耐药模式的预处理效果。
我们的结果表明，用ATCC 4356上清液预处理可影响[细菌名称]菌株对头孢曲松的耐药性，但对其他抗生素的耐药性无影响。此外，浓度大于2%的乳酸杆菌培养上清液对ATCC 13880的群体运动能力有影响并抑制了它。
益生菌及其代谢产物有能力抑制抗生素耐药性和群体运动性等毒力因子，可作为抗生素的替代品。
