Linch D C, Cawley J C, Worman C P, Galvin M C, Roberts B E, Callard R E, Beverley P C
Br J Haematol. 1981 May;48(1):137-45. doi: 10.1111/j.1365-2141.1981.00137.x.
Morphological, surface-marker and culture studies were performed in three patients who had in common neutropenia and an excess of lymphocytes in the bone marrow, but who differed from each other in certain regards such as age and peripheral lymphocyte numbers. All three patients had an increased proportion of E-rosetting cells bearing Fc receptors for IgG. These cells were shown to be T lymphocytes by staining with monoclonal anti-T-cell sera and their subset phenotype was established as OKT4- OKT8+; in addition, a variable proportion of the cells was Ia+. The functional significance of this expanded subpopulation of T cells was not clear, but it was shown that they did not inhibit colony formation in vitro.
对三名患者进行了形态学、表面标志物和培养研究。这三名患者均有中性粒细胞减少和骨髓淋巴细胞增多的共同症状，但在年龄和外周淋巴细胞数量等某些方面存在差异。所有三名患者中，带有IgG Fc受体的E花环形成细胞比例均增加。通过用单克隆抗T细胞血清染色显示这些细胞为T淋巴细胞，并且其亚群表型确定为OKT4 - OKT8 +；此外，可变比例的细胞为Ia +。这种T细胞亚群扩增的功能意义尚不清楚，但已表明它们在体外不抑制集落形成。
