两名中性粒细胞减少症患者中参与抑制粒细胞生成的T淋巴细胞属于细胞毒性/抑制性（T3+T8+）亚群。
T lymphocytes involved in inhibition of granulopoiesis in two neutropenic patients are of the cytotoxic/suppressor (T3+T8+) subset.
作者信息
Bagby G C
出版信息
J Clin Invest. 1981 Dec;68(6):1597-600. doi: 10.1172/jci110415.
Abstract
T lymphocyte-mediated bone marrow failure is a recently recognized clinical disorder, but the T lymphocyte subsets responsible for mediating the inhibitory effect have not been identified. We obtained T lymphocytes from the bone marrow of two patients with T lymphocyte-mediated granulopoietic failure, exposed them to monoclonal antibodies (OKT3, OKT4, and OKT8) in cytotoxicity assays, then recombined the treated T cells with autologous T-depleted marrow cells in clonal assays for granulocyte/macrophage progenitors (CFU-GM). Treatment of T cells with OKT3 and OKT8 abrogated their granulopoietic inhibitory effect but treatment with OKT4 did not. Therefore, in these two patients, the lymphocytes that played a role in the inhibition of granulopoiesis were of the cytotoxic/suppressor subset.
摘要
T淋巴细胞介导的骨髓衰竭是一种最近才被认识的临床病症，但介导抑制作用的T淋巴细胞亚群尚未明确。我们从两名患有T淋巴细胞介导的粒细胞生成衰竭患者的骨髓中获取T淋巴细胞，在细胞毒性试验中将它们暴露于单克隆抗体（OKT3、OKT4和OKT8），然后在粒细胞/巨噬细胞祖细胞（CFU-GM）的克隆试验中，将经处理的T细胞与自体去除T细胞的骨髓细胞重新组合。用OKT3和OKT8处理T细胞消除了它们的粒细胞生成抑制作用，但用OKT4处理则没有。因此，在这两名患者中，对粒细胞生成起抑制作用的淋巴细胞属于细胞毒性/抑制性子集。
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