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功能不同的T细胞亚群对人空细胞成熟的影响。

Effects of functionally-distinct T-cell subsets on the maturation of null cells in man.

作者信息

Strelkauskas A J, Andrew J A, Callery R T, Ozer H

出版信息

Immunology. 1981 Jun;43(2):379-86.

PMID:7019055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555017/
Abstract

We have found that the 'null' cell population (negative for surface immunoglobulin and for E-rosette formation) includes cells which can develop surface immunoglobulin and secrete immunoglobulin in culture. The apparent 'maturation' of these null cells to immunoglobulin-secreting B cells was enhanced by T cells and may require T cells. T-cell subsets shown previously to have a helper effect on immunoglobulin secretion by peripheral blood B cells accelerated this maturation process, whereas subsets without helper effects on peripheral blood B cells did not.

摘要

我们发现，“空”细胞群体（表面免疫球蛋白和E花环形成均为阴性）包含在培养中可发育出表面免疫球蛋白并分泌免疫球蛋白的细胞。这些空细胞向分泌免疫球蛋白的B细胞的明显“成熟”过程受到T细胞的增强作用，且可能需要T细胞。先前显示对外周血B细胞的免疫球蛋白分泌具有辅助作用的T细胞亚群加速了这一成熟过程，而对外周血B细胞无辅助作用的亚群则不然。

相似文献

1
Effects of functionally-distinct T-cell subsets on the maturation of null cells in man.功能不同的T细胞亚群对人空细胞成熟的影响。
Immunology. 1981 Jun;43(2):379-86.
2
Induction of immunoglobulin-secreting cells in the allogeneic mixed leukocyte reaction: regulation by helper and suppressor lymphocyte subsets in man.同种异体混合淋巴细胞反应中免疫球蛋白分泌细胞的诱导：人类辅助性和抑制性淋巴细胞亚群的调节
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Analysis of the immunoglobulin isotype expression by peripheral blood rosette forming cells in chickens.鸡外周血玫瑰花结形成细胞免疫球蛋白同种型表达的分析
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Immunologic functions of isolated human lymphocyte subpopulations. VI. Further characterization of the surface Ig negative, E rosette negative (null cell) subset.分离的人淋巴细胞亚群的免疫功能。VI. 表面免疫球蛋白阴性、E 玫瑰花结阴性（裸细胞）亚群的进一步特征分析。
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本文引用的文献

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Chemical coupling of enzymes to cross-linked dextran ('Sephadex').酶与交联葡聚糖（“葡聚糖凝胶”）的化学偶联
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Immunologic functions of isolated human lymphocyte subpopulations. VI. Further characterization of the surface Ig negative, E rosette negative (null cell) subset.分离的人淋巴细胞亚群的免疫功能。VI. 表面免疫球蛋白阴性、E 玫瑰花结阴性（裸细胞）亚群的进一步特征分析。
J Immunol. 1975 Dec;115(6):1483-7.
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Human peripheral Null lymphocytes. I. Isolation, immunological and functional characterization.人外周无效淋巴细胞。I. 分离、免疫及功能特性
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Enumeration and isolation of human T and B lymphocytes by rosette formation with antibody-coated erythrocytes.通过与抗体包被红细胞形成玫瑰花结来计数和分离人T淋巴细胞和B淋巴细胞。
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Markers of human T cell subsets identified by alloantisera.通过同种异体抗血清鉴定的人类T细胞亚群标志物。
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Surface markers and electron microscopy of human blood L cells: a comparison with T and B lymphocytes.人血L细胞的表面标志物与电子显微镜观察：与T淋巴细胞和B淋巴细胞的比较
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Comparison of the direct antiglobulin rosetting reaction with direct immunofluorescence in the detection of surface membrane immunoglobulin on human peripheral blood lymphocytes.直接抗球蛋白玫瑰花结反应与直接免疫荧光法在检测人外周血淋巴细胞表面膜免疫球蛋白中的比较。
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10
T-cell regulation of human peripheral blood B-cells responsiveness.人外周血B细胞反应性的T细胞调节
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