抗菌剂对人多形核白细胞（PMN）清除32P标记的大肠杆菌的影响。
Effects of antibacterial agents on the elimination of 32P-labelled Escherichia coli by human polymorphonuclear cells (PMN).
作者信息
Melby K, Midtvedt T
出版信息
Acta Pathol Microbiol Scand B. 1981 Apr;89(2):129-31. doi: 10.1111/j.1699-0463.1981.tb00164_89b.x.
Abstract
Eight antibacterial agents, cephalothin, colistin, doxycycline, erythromycin, gentamicin, chloramphenicol, oxytetracycline and trimethoprim were studied in a phagocytic system using human polymorphonuclear cells (PMN) and a radio-labelled strain of Escherichia coli as test microbe. 100 micrograms/ml of either doxycycline or trimethoprim appeared to reduce the elimination of labelled products from the PMN. The effect of doxycycline was independent of heat-labile serum factors.
摘要
使用人多形核细胞（PMN）和放射性标记的大肠杆菌菌株作为测试微生物，在吞噬系统中研究了八种抗菌剂，即头孢噻吩、多粘菌素、强力霉素、红霉素、庆大霉素、氯霉素、土霉素和甲氧苄啶。100微克/毫升的强力霉素或甲氧苄啶似乎会减少PMN对标记产物的清除。强力霉素的作用不依赖于热不稳定的血清因子。
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