氢化可的松对大鼠多形核中性粒细胞（PMN）体外摄取和清除³²P标记大肠杆菌的影响。
Influence of hydrocortisone on uptake and elimination of 32P-labelled E. coli by rat polymorphonuclear neutrophils (PMN) in vitro.
作者信息
Baardsen A
出版信息
Acta Pathol Microbiol Scand C. 1976 Apr;84(2):131-4. doi: 10.1111/j.1699-0463.1976.tb00010.x.
Abstract
Hydrocortisone was tested for inhibition of uptake and of elimination of E. coli by monolayers of rat peritoneal PMN. 32P was used as label of the bacteria and their degradation products eliminated from the phagocytes. The cellular uptake was reduced by hydrocortisone (1-2 mg per ml) both in the presence and absence of serum, while the elimination of bacterial label was reduced by 0.5 mg per ml and higher concentrations of the drug.
摘要
用氢化可的松检测其对大鼠腹膜多形核中性粒细胞（PMN）单层摄取和清除大肠杆菌的抑制作用。使用³²P作为细菌及其从吞噬细胞中清除的降解产物的标记物。无论有无血清存在，氢化可的松（每毫升1 - 2毫克）均能降低细胞摄取，而每毫升0.5毫克及更高浓度的该药物能降低细菌标记物的清除。
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