Anderson G G, Rotchell Y, Kaiser D G
Am J Obstet Gynecol. 1981 Jul 15;140(6):699-701. doi: 10.1016/0002-9378(81)90207-6.
Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels to the fetal compartment. Since methylprednisolone may have less of an infection-potentiating effect than other commonly used corticosteroids, use of it as a stimulator of fetal lung surfactant deserves further investigation.
七名足月正常分娩的产妇在分娩前不久静脉注射了125毫克琥珀酸甲泼尼龙。对母体和脐带血血浆样本的分析表明，皮质类固醇的琥珀酸盐和游离醇形式均以药理水平转运至胎儿体内。由于甲泼尼龙可能比其他常用皮质类固醇具有更小的感染增强作用，因此将其用作胎儿肺表面活性物质的刺激剂值得进一步研究。
