Stahl Peter J, Stember Doron S, Hsiao Wayland, Schlegel Peter N
James Buchanan Brady Department of Urology, Weill Cornell Medical College, New York, New York, USA.
Clin Obstet Gynecol. 2010 Dec;53(4):815-27. doi: 10.1097/GRF.0b013e3181f980b3.
Fertility preservation is feasible in the majority of men. Herein, we review the reproductive toxicities of commonly encountered clinical threats to male fertility, including cancer, radiotherapy, chemotherapy, surgery, and nonmalignant diseases treated with immunosuppression. Other scenarios, in which fertility preservation may be considered, such as Klinefelter syndrome, acute testicular injury, and sudden unexpected death, are also discussed. We provide an algorithmic approach to fertility preservation in men, and review strategies for sperm acquisition in cases of ejaculatory dysfunction and azoospermia. Lastly, emerging options for fertility preservation in prepubertal boys are discussed.
对大多数男性来说，生育力保存是可行的。在此，我们综述了临床上常见的对男性生育力构成威胁的因素的生殖毒性，包括癌症、放疗、化疗、手术以及采用免疫抑制治疗的非恶性疾病。还讨论了其他可考虑生育力保存的情况，如克兰费尔特综合征、急性睾丸损伤和意外猝死。我们提供了一种男性生育力保存的算法方法，并综述了射精功能障碍和无精子症病例中获取精子的策略。最后，讨论了青春期前男孩生育力保存的新选择。
