速尿和利尿酸对人体肾素释放的影响。神经反射控制机制的证据。

Renin release after furosemide and ethacrynic acid in man. Evidence for neural reflex control mechanisms.

作者信息

Hummerich W, Konrads A, Krause D K, Fischer J H, Kaufmann W

出版信息

Klin Wochenschr. 1981 Jul 15;59(14):791-5. doi: 10.1007/BF01724685.

PMID:7021994

Abstract

The mechanisms of renin release after furosemide (F) and ethacrynic acid (EA) in man were examined. We evaluated whether acute volume shifts within the low pressure system after F induce renin release via neural pathways. Immersion in a water-bath or beta-blockade reduced the increase of plasma renin concentration after F but not after EA. It is concluded that acute renin release after F but not after EA in man is partially due to neurally mediated reflexes originating from volume receptors in the cardiopulmonary area.

摘要

研究了速尿（F）和依他尼酸（EA）后人体肾素释放的机制。我们评估了F后低压系统内的急性容量变化是否通过神经途径诱导肾素释放。浸入水浴或使用β受体阻滞剂可降低F后血浆肾素浓度的升高，但对EA后无此作用。结论是，人体中F后而非EA后的急性肾素释放部分归因于源自心肺区域容量感受器的神经介导反射。