Noda Y, Fukiyama K, Kumamoto K, Takishita S, Eto T, Kawasaki T, Omae T
Jpn Circ J. 1982 Jun;46(6):552-8. doi: 10.1253/jcj.46.552.
Plasma renin activity (PRA) was serially determined 0, 15, 30, 60 and 120 min following administration of furosemide in a dose of 40 mg intravenously (i.v.) and 80 mg orally (p.o.) at a one week interval in 10 healthy men. Following i.v. furosemide administration, PRA increased rapidly and reached a plateau level of 6.1 +/- 1.0 ng/ml/h (222 +/- 44% of the control), at 15 min and remained at about the same level throughout the remaining period of the study. In contrast, PRA increased progressively to a maximum level of 5.5 +/- 0.7 ng/ml/h (285 +/- 53% of the control), 120 min after p.o. furosemide. In case of p.o. furosemide, the increase in PRA was dependent on the doses used per body weight, and was significantly correlated with the cumulative sodium excretion by itself, or the cumulative sodium excretion adjusted by either the leanness index or the body surface area. Such relationships were not apparent after i.v. furosemide. These findings suggest that the response of renin release to furosemide in healthy men differs with the routes of administration and renin release with p.o. furosemide may be largely due to a net sodium loss, while mechanism(s) other than sodium loss may be involved in the early hypersecretion of renin with i.v. administration of furosemide.
在10名健康男性中，以一周的间隔，静脉注射（i.v.）40mg和口服（p.o.）80mg速尿后，于0、15、30、60和120分钟连续测定血浆肾素活性（PRA）。静脉注射速尿后，PRA迅速升高，在15分钟时达到6.1±1.0ng/ml/h的平台水平（为对照值的222±44%），并在研究的剩余时间内维持在大致相同的水平。相比之下，口服速尿后120分钟，PRA逐渐升高至最高水平5.5±0.7ng/ml/h（为对照值的285±53%）。对于口服速尿，PRA的升高取决于每体重所用的剂量，并且与自身的累积钠排泄量，或根据瘦体重指数或体表面积调整后的累积钠排泄量显著相关。静脉注射速尿后，这种关系不明显。这些发现表明，健康男性中肾素释放对速尿的反应因给药途径而异，口服速尿时肾素释放可能主要归因于净钠丢失，而静脉注射速尿时肾素早期分泌过多可能涉及钠丢失以外的机制。
