Gabriel R, Baylor P
Postgrad Med J. 1981 Feb;57(664):71-4. doi: 10.1136/pgmj.57.664.71.
Eleven plasma variables have been studied in 18 elderly patients with cardiac oedema treated with bendrofluazide, frusemide and bumetanide, using a fully balanced, cross-over trial design. Bumetanide caused the least disturbance of plasma potassium and bendrofluazide the greatest. Frusemide produced an intermediate effect. The difference between the changes in plasma potassium produced by bumetanide and bendrofluazide was significant (P less than 0.02).
采用完全平衡的交叉试验设计,对18例接受苄氟噻嗪、速尿和布美他尼治疗的心性水肿老年患者的11种血浆变量进行了研究。布美他尼对血浆钾的干扰最小,苄氟噻嗪最大。速尿产生的影响居中。布美他尼和苄氟噻嗪引起的血浆钾变化差异具有显著性(P小于0.02)。