Lawson D H, Boddy K, Gray J M, Mahaffey M, Mills E
Q J Med. 1976 Jul;45(179):469-78.
Plasma, blood cell, and total body potassium levels were measured serially in 21 patients receiving long-term diuretics for the treatment of cardiac oedema and the results compared with similar measurements in 10 control subjects. Initially, all diuretic recipients received potassium chloride supplements. However, in 17 of the 21 subjects these were discontinued and measurements of potassium status were repeated regularly thereafter. No significant fall in the measured indicators of potassium status were observed in the patients in whom potassium was withdrawn; however, in one subject with persistent cardiac failure who presented with hypokalaemia this was not corrected even after intensive potassium supplementation. It is concluded that for those taking a normal diet who are free of any major gastro-intestinal disorder, routine potassium supplementation is unnecessary, and might indeed occasionally prove harmful.
对21例因治疗心源性水肿而长期服用利尿剂的患者，连续测定其血浆、血细胞和全身钾水平，并将结果与10名对照受试者的类似测量结果进行比较。最初，所有接受利尿剂治疗的患者均补充氯化钾。然而，21名受试者中有17名停止补充氯化钾，此后定期重复测量钾状态。在停用钾的患者中，未观察到钾状态测量指标的显著下降；然而，有一名患有持续性心力衰竭并出现低钾血症的受试者，即使在强化补钾后，低钾血症仍未得到纠正。结论是，对于饮食正常且无任何重大胃肠道疾病的人，常规补钾是不必要的，而且偶尔可能确实有害。
