Rossmann M G, Argos P
Annu Rev Biochem. 1981;50:497-532. doi: 10.1146/annurev.bi.50.070181.002433.
After some general remarks on protein structure, there follows a discussion on primary, secondary, and tertiary organization. The account of primary structure includes a discussion of the conformation of disulfide bonds. Types of helices, sheets, and turns are described in the section on secondary structure, followed by a discussion of super-secondary structure and the effects of metals and prosthetic groups of protein fold. The crux of the review lies in an examination of tertiary structure, or specifically of domains that are defined, in part, as functional units within a polypeptide chain. An assembly of domains can in turn result in a protein whose function is quite sophisticated. Some consideration of domain recognition is given in the section on taxonomy and in the appendix. The key part of the tertiary structure section concentrates on a taxonomic protein classification dependent not only on structure but also on function. A discussion of the requirements by quaternary structure on a fold are omitted in this review. Finally, no review of this kind can escape a discussion of evolutionary convergence and divergence.
在对蛋白质结构进行一些一般性论述之后，接着是关于一级、二级和三级结构组织的讨论。一级结构的阐述包括对二硫键构象的讨论。螺旋、片层和转角的类型在二级结构部分进行了描述，随后是关于超二级结构以及金属和蛋白质折叠辅基的影响的讨论。该综述的关键在于对三级结构的考察，或者具体而言，是对部分被定义为多肽链内功能单元的结构域的考察。结构域的组装进而可以产生一种功能相当复杂的蛋白质。在分类学部分和附录中对结构域识别进行了一些探讨。三级结构部分的关键内容集中在一种不仅依赖于结构而且依赖于功能的蛋白质分类学分类上。本综述省略了对四级结构对折叠的要求的讨论。最后，此类综述不可避免地要讨论进化趋同和趋异。
