Solomon L R, Cairns S A, Lawler W, Johnson R W, Mallick N P
Clin Nephrol. 1981 Jul;16(1):44-50.
A patient developed recurrent IgM proliferative glomerulonephritis and a nephrotic syndrome following HLA-identical living donor renal transplantation. Two intensive five-day courses of plasma exchange were followed by sustained reduction of proteinuria. Renal function has remained normal at all times. Immune complex sizing revealed a high titer of middle range complexes (mol. wt. 1 x 10(6) daltons app.); immune complex clearance following an antigen load was not improved by plasma exchange suggesting no alteration of reticulo-endothelial function. Possible mechanisms of benefit are discussed.
一名患者在接受 HLA 配型相同的活体供肾肾移植后发生复发性 IgM 增殖性肾小球肾炎和肾病综合征。进行了两个为期五天的强化血浆置换疗程，随后蛋白尿持续减少。肾功能一直保持正常。免疫复合物大小分析显示存在高滴度的中等大小复合物（分子量约为 1×10⁶ 道尔顿）；抗原负荷后血浆置换并未改善免疫复合物清除情况，提示网状内皮系统功能未改变。文中讨论了可能的获益机制。
