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血流动力学

Mechanics of blood flow.

作者信息

Skalak R, Keller S R, Secomb T W

出版信息

J Biomech Eng. 1981 May;103(2):102-15. doi: 10.1115/1.3138253.

DOI:10.1115/1.3138253
PMID:7024641
Abstract

The historical development of the mechanics of blood flow can be traced from ancient times, to Leonardo da Vinci and Leonhard Euler and up to the present times with increasing biological knowledge and mathematical analysis. In the last two decades, quantitative and numerical methods have steadily given more complete and precise understanding. In the arterial system wave propagation computations based on nonlinear one-dimensional modeling have given the best representation of pulse wave propagation. In the veins, the theory of unsteady flow in collapsible tubes has recently been extensively developed. In the last decade, progress has been made in describing the blood flow at junctions, through stenoses, in bends and in capillary blood vessels. The rheological behavior of individual red blood cells has been explored. A working model consists of an elastic membrane filled with viscous fluid. This model forms a basis for understanding the viscous and viscoelastic behavior of blood.

摘要

血流动力学的历史发展可以追溯到古代,经过列奥纳多·达·芬奇和莱昂哈德·欧拉,直至当代,随着生物学知识和数学分析的不断增加。在过去二十年中,定量和数值方法不断带来更完整、精确的理解。在动脉系统中,基于非线性一维建模的波动传播计算对脉搏波传播给出了最佳描述。在静脉方面,可塌陷管内非定常流动理论最近得到了广泛发展。在过去十年里,在描述血管交汇处、狭窄处、弯曲处及毛细血管中的血流方面取得了进展。单个红细胞的流变行为也已得到探索。一个工作模型由充满粘性流体的弹性膜组成。该模型为理解血液的粘性和粘弹性行为奠定了基础。

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