Huskisson E C, Scott J, Christophidis N
Rheumatol Rehabil. 1981 Aug;20(3):174-6. doi: 10.1093/rheumatology/20.3.174.
Indoprofen, despite its relatively short plasma half-life, was just as effective given twice daily as when the same daily total was given in four divided doses. There was a trend in favour of the twice daily regime for changes in morning pain and the duration of morning stiffness. Preferences were equally divided between the two regimes and efficacy was the usual reason for patients preferring one or other. Side-effects were no more frequent with the twice daily regime. Pharmacokinetics are no substitute for clinical experiment in planning the dosage regime of a non-steroidal anti-inflammatory drug.
尽管吲哚美辛的血浆半衰期相对较短，但每日给药两次与将相同的每日总量分四次给药的效果相同。在改善晨痛和晨僵持续时间方面，有倾向于每日给药两次方案的趋势。患者对两种方案的偏好相同，疗效是患者选择其中一种方案的常见原因。每日给药两次方案的副作用并不更频繁。在规划非甾体抗炎药的给药方案时，药代动力学不能替代临床试验。
