吸入香烟烟雾会特异性抑制大鼠体内对前列环素的降压反应。
Cigarette smoke inhalation specifically inhibits depressor responses to prostacyclin in the rat.
作者信息
Boura A L, Hui S C, Walters W A
出版信息
Br J Pharmacol. 1981 May;73(1):3-5. doi: 10.1111/j.1476-5381.1981.tb16762.x.
Abstract
Studies have been made of the effects of prior exposure to cigarette smoke on cardiovascular responses of the anaesthetized rat to arachidonic acid, prostaglandin E2 (PGE2), PGF2 alpha and PGI2. When compared with a control group, falls in systolic and diastolic blood pressure and tachycardia following intravenous PGI2 were significantly reduced in those animals exposed to smoke 1 and 24 h previously. Responses 48 h after exposure were not significantly different. Pressor effects of PGF2 alpha and depressor responses to arachidonic acid and PGE2 were not significantly affected these times. It is suggested that the specific and long lasting attenuation of the effects of PGI2 which occurs following cigarette smoke inhalation could contribute to both acute cardiovascular changes and the circulatory diseases associated with smoking.
摘要
已经对预先暴露于香烟烟雾对麻醉大鼠对花生四烯酸、前列腺素E2（PGE2）、前列腺素F2α和前列环素（PGI2）的心血管反应的影响进行了研究。与对照组相比，在1小时和24小时前暴露于烟雾的动物中，静脉注射PGI2后收缩压和舒张压的下降以及心动过速明显减轻。暴露48小时后的反应没有显著差异。在这些时间，PGF2α的升压作用以及对花生四烯酸和PGE2的降压反应没有受到显著影响。有人提出，吸入香烟烟雾后发生的PGI2作用的特异性和持久减弱可能导致急性心血管变化以及与吸烟相关的循环系统疾病。
相似文献
1
Cigarette smoke inhalation specifically inhibits depressor responses to prostacyclin in the rat.吸入香烟烟雾会特异性抑制大鼠体内对前列环素的降压反应。
Br J Pharmacol. 1981 May;73(1):3-5. doi: 10.1111/j.1476-5381.1981.tb16762.x.
2
Effects of endogenous and synthetic prostanoids, the thromboxane A2 receptor agonist U-46619 and arachidonic acid on [3H]-noradrenaline release and vascular tone in rat isolated kidney.内源性和合成类前列腺素、血栓素A2受体激动剂U-46619及花生四烯酸对大鼠离体肾脏中[3H]-去甲肾上腺素释放及血管张力的影响
Br J Pharmacol. 1989 Jul;97(3):819-28. doi: 10.1111/j.1476-5381.1989.tb12021.x.
3
Central cardiovascular activity of prostaglandin E2, prostaglandin F2 alpha and prostacyclin.前列腺素E2、前列腺素F2α和前列环素的中枢心血管活性。
Prostaglandins. 1981 Jun;21(6):899-904. doi: 10.1016/0090-6980(81)90159-3.
4
Captopril potentiates depressor responses to arachidonic acid in the rat.卡托普利可增强大鼠对花生四烯酸的降压反应。
Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):679-83. doi: 10.1111/j.1440-1681.1982.tb00841.x.
5
Chronic nicotine treatment enhances the depressor responses to arachidonic acid in the rat.慢性尼古丁处理可增强大鼠对花生四烯酸的降压反应。
Pharmacology. 1991;42(5):257-61. doi: 10.1159/000138806.
6
Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prostaglandin F1alpha with those of prostaglandin E2 in rats and rabbits.前列环素、6-氧代前列腺素F1α与前列腺素E2对大鼠和家兔血管降压作用的比较。
Br J Pharmacol. 1978 Jan;62(1):125-30. doi: 10.1111/j.1476-5381.1978.tb07014.x.
7
Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat.花生四烯酸、前列腺素E2、前列腺素F2α、前列腺素D2和前列环素对大鼠胃分泌的中枢神经系统效应
Br J Pharmacol. 1983 Oct;80(2):255-62. doi: 10.1111/j.1476-5381.1983.tb10028.x.
8
Effect of PGD2, PGE2 PGF2 alpha and PGI on blood pressure, heart rate and plasma catecholamine responses to spinal cord stimulation in the rat.前列腺素D2、前列腺素E2、前列腺素F2α和前列环素对大鼠脊髓刺激引起的血压、心率及血浆儿茶酚胺反应的影响。
Prostaglandins. 1981 Feb;21(2):189-206. doi: 10.1016/0090-6980(81)90137-4.
9
Blood pressure and cardiac tissue responses to prostacyclin (PGI2) in various species.不同物种中血压和心脏组织对前列环素（PGI2）的反应。
Can J Physiol Pharmacol. 1982 Feb;60(2):134-9. doi: 10.1139/y82-022.
10
Effects of prostacyclin on cardiovascular reflexes from the ventricular epicardium of the dog: comparison with the effects of prostaglandin E2.前列环素对犬心室心外膜心血管反射的影响：与前列腺素E2作用的比较。
Prostaglandins. 1981 Jun;21(6):905-15. doi: 10.1016/0090-6980(81)90160-x.
引用本文的文献
1
Cigarette smoking does not attenuate the cardiovascular effects of epoprostenol (prostacyclin) in humans.吸烟不会减弱依前列醇（前列环素）对人体的心血管作用。
Br J Clin Pharmacol. 1982 Jul;14(1):97-8. doi: 10.1111/j.1365-2125.1982.tb04940.x.
2
The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats.
Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):221-8. doi: 10.1007/BF03190102.
本文引用的文献
1
Nicotine inhibits hypoxia- and arachidonate-induced release of prostacyclin-like activity in rabbit hearts.尼古丁可抑制兔心脏中由缺氧和花生四烯酸诱导的前列环素样活性的释放。
Br J Pharmacol. 1980 Aug;69(4):545-9. doi: 10.1111/j.1476-5381.1980.tb07901.x.
2
Hepatic metabolism of prostacyclin (PGI2) in the rabbit: formation of a potent novel inhibitor of platelet aggregation.兔体内前列环素（PGI2）的肝脏代谢：一种强效新型血小板聚集抑制剂的形成。
Biochem Biophys Res Commun. 1980 Mar 28;93(2):486-94. doi: 10.1016/0006-291x(80)91103-1.
3
Cigarette smoke: stimulatory effect of metabolism of 3,4--benzpyrene by enzymes in rat lung.香烟烟雾：大鼠肺中酶对3,4-苯并芘代谢的刺激作用。
Life Sci I. 1971 Feb 15;10(4):215-21. doi: 10.1016/0024-3205(71)90250-5.
4
The release and fate of vaso-active hormones in the circulation.血管活性激素在循环中的释放与转归
Br J Pharmacol. 1969 Feb;35(2):209-42. doi: 10.1111/j.1476-5381.1969.tb07982.x.
5
Possible contributions of endogenous prostaglandins to the control of blood pressure.
Circ Res. 1975 Jun;36(6 Suppl 1):68-75. doi: 10.1161/01.res.36.6.68.
6
Effects of nicotine on cardiac prostaglandin and platelet thromboxane synthesis.尼古丁对心脏前列腺素和血小板血栓素合成的影响。
Br J Pharmacol. 1978 Dec;64(4):559-63. doi: 10.1111/j.1476-5381.1978.tb17318.x.
7
Nicotine inhibits the release of 6-keto-prostaglandin F1alpha from the isolated perfused rabbit heart.尼古丁抑制离体灌注兔心脏中6-酮-前列腺素F1α的释放。
Acta Physiol Scand. 1978 May;103(1):107-9. doi: 10.1111/j.1748-1716.1978.tb06196.x.
8
The effects of cigarette smoke exposure on testosterone metabolism in the isolated perfused rat lung.香烟烟雾暴露对离体灌流大鼠肺脏中睾酮代谢的影响。
J Steroid Biochem. 1978 Apr;9(4):365-8. doi: 10.1016/0022-4731(78)90632-5.
9
Effects of cigarette smoke on the metabolism of vasoactive hormones in rat isolated lungs.香烟烟雾对大鼠离体肺中血管活性激素代谢的影响。
Br J Pharmacol. 1979 Mar;65(3):495-9. doi: 10.1111/j.1476-5381.1979.tb07857.x.
10
Effects of single and repeated cigarette smoke-exposures on the activities of aryl hydrocarbon hydroxylase, epoxide hydratase and UDP glucuronosyltransferase in rat lung, kidney and small intestinal mucosa.单次及反复香烟烟雾暴露对大鼠肺、肾及小肠黏膜中芳烃羟化酶、环氧化物水解酶和UDP葡糖醛酸基转移酶活性的影响。
Res Commun Chem Pathol Pharmacol. 1977 May;17(1):101-14.
Zotero 插件