Dixon A Y, McGregor D H, Lee S H
Hum Pathol. 1981 Aug;12(8):739-47. doi: 10.1016/s0046-8177(81)80176-1.
The clinicopathologic features of 50 noninfiltrating angiolipomas are presented, with a detailed ultrastructural study of five cases and immunoflourescence study of one case. The clinical presentation, including age, location, and associated symptoms, is discussed. Pertinent light microscopic findings, including features helpful in diagnosing borderline lesions, are described. The first ultrastructural and immunofluorescence study of this entity is presented. Among various ultrastructural findings, there appear to be decreased numbers of Weibel-Palade bodies in the endothelial cells of all angiolipomas studied. The relationship of Weibel-Palade bodies to the functional state of the cell and their possible procoagulative effect are discussed. Immunofluorescence and ultrastructural studies further suggest that endothelial disruption and endothelial fibrinogen contribute to the fibrin thrombus formation typically found in angiolipomas.
本文介绍了50例非浸润性血管脂肪瘤的临床病理特征，并对其中5例进行了详细的超微结构研究，对1例进行了免疫荧光研究。讨论了临床表现，包括年龄、部位及相关症状。描述了相关的光镜检查结果，包括有助于诊断临界性病变的特征。本文首次对该实体进行了超微结构和免疫荧光研究。在各种超微结构发现中，在所研究的所有血管脂肪瘤的内皮细胞中，魏-帕小体的数量似乎减少。讨论了魏-帕小体与细胞功能状态的关系及其可能的促凝血作用。免疫荧光和超微结构研究进一步表明，内皮细胞破坏和内皮纤维蛋白原促成了血管脂肪瘤中典型的纤维蛋白血栓形成。
