Kimura M, Waki I, Chujo T, Kikuchi T, Hiyama C, Yamazaki K, Tanaka O
J Pharmacobiodyn. 1981 Jun;4(6):410-7. doi: 10.1248/bpb1978.4.410.
Some fractions extracted from ginseng radix (HAKUSAN) caused hypoglycemic effect on alloxan diabetic mice. The effect was abolished by the i.v. injection of antisera against bovine insulin. The same doses of the ginseng fraction (10--50 mg/kg) produced an increase in the blood insulin level in alloxan diabetic mice. Normal mice loaded i.p. with glucose (2 g/kg or more) showed also such an increase. Insulin release from perfused rat pancreases was stimulated by the ginseng fraction (0.2 mg/ml), but the potency was not stronger than that of the sulfonylureas. It was demonstrated that glucose-induced insulin release was marked in the presence of the ginseng fraction. Impaired insulin responses to glucose in alloxan diabetic rats were increased by the fraction (0.5 mg/ml) to or above the control responses in normal rats. The enhanced effect was observed also in the presence of 100 microgram/ml cycloheximide. These results indicate that some ginseng fractions stimulated insulin release, especially glucose-induced insulin release from pancreatic islets and thereby lowered the blood glucose level.
从人参根（白术）中提取的某些成分对四氧嘧啶糖尿病小鼠具有降血糖作用。静脉注射抗牛胰岛素抗血清可消除该作用。相同剂量的人参成分（10 - 50毫克/千克）可使四氧嘧啶糖尿病小鼠的血液胰岛素水平升高。腹腔注射葡萄糖（2克/千克或更多）的正常小鼠也出现这种升高。人参成分（0.2毫克/毫升）可刺激灌注大鼠胰腺释放胰岛素，但其效力不强于磺酰脲类药物。结果表明，在人参成分存在的情况下，葡萄糖诱导的胰岛素释放明显增加。四氧嘧啶糖尿病大鼠对葡萄糖的胰岛素反应受损，该成分（0.5毫克/毫升）可使其增加至正常大鼠对照反应水平或以上。在100微克/毫升环己酰亚胺存在的情况下也观察到增强作用。这些结果表明，某些人参成分可刺激胰岛素释放，尤其是胰腺胰岛中葡萄糖诱导的胰岛素释放，从而降低血糖水平。
