Kimura M, Waki I, Tanaka O, Nagai Y, Shibata S
J Pharmacobiodyn. 1981 Jun;4(6):402-9. doi: 10.1248/bpb1978.4.402.
Three methods of fractionation of ginseng radix (Panax ginseng C.A. MEYER) components for a survey of hypoglycemic principle in alloxan diabetic mice were conducted and three groups of hypoglycemic principle in alloxan diabetic mice were conducted and three groups of components tested; fat-soluble components, ginseng saponins and a third component with hypoglycemic activity. Pharmacological sequential trials of the fractionation yielded a most active fraction which was about 100-fold more effective than the original water-soluble extract of the ginseng radix. The ED50 value was 0.4 mg/kg in lowering the blood level of glucose in alloxan diabetic mice. It was demonstrated that some ginseng fractions inhibited epinephrine-induced transient hyperglycemia in mice, increased glycogen content in rat liver, decreased the blood level of acetone bodies in alloxan diabetic mice, and inhibited the release of free fatty acid from rat epididymal fat pad. The results showed that hypoglycemic components existed in a new component of ginseng radix which is different from saponin.
为研究人参根（人参C.A.迈耶）成分对四氧嘧啶糖尿病小鼠的降血糖原理，进行了三种分离人参根成分的方法，并对三组成分进行了测试；脂溶性成分、人参皂苷和具有降血糖活性的第三种成分。对分离物进行的药理学序贯试验产生了一种活性最强的分离物，其效力比人参根的原始水溶性提取物高约100倍。在降低四氧嘧啶糖尿病小鼠血糖水平方面，其半数有效剂量（ED50）值为0.4mg/kg。结果表明，一些人参分离物可抑制小鼠肾上腺素诱导的短暂性高血糖，增加大鼠肝脏中的糖原含量，降低四氧嘧啶糖尿病小鼠的血酮体水平，并抑制大鼠附睾脂肪垫中游离脂肪酸的释放。结果表明，人参根中存在一种不同于皂苷的新成分，其中含有降血糖成分。
