Nakashima N, Kimura I, Kimura M, Matsuura H
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
J Nat Prod. 1993 Mar;56(3):345-50. doi: 10.1021/np50093a006.
A hot-H2O extract of rhizomes of Anemarrhena asphodeloides, the Japanese sino-medicine "chimo," lowered the blood glucose level in alloxan-diabetic mice. Hypoglycemic activity-guided fractionation isolated a new glycoside, pseudoprototimosaponin AIII [1], which was compared with chemically known prototimosaponin AIII [2]. These compounds exhibited hypoglycemic effects in a dose-dependent manner in streptozotocin-diabetic mice but showed no effects on glucose uptake and insulin release, suggesting that the hypoglycemic mechanism may be due to inhibition of hepatic gluconeogenesis and/or glycogenolysis.
日本汉方药“知母”的根茎热水提取物可降低四氧嘧啶糖尿病小鼠的血糖水平。通过降血糖活性导向分离得到一种新的糖苷，伪原知母皂苷AIII[1]，并将其与化学合成的原知母皂苷AIII[2]进行比较。这些化合物在链脲佐菌素糖尿病小鼠中呈剂量依赖性地表现出降血糖作用，但对葡萄糖摄取和胰岛素释放无影响，这表明其降血糖机制可能是由于抑制肝糖异生和/或糖原分解。
