诱导分泌大量甲胎蛋白的肝癌形成。
Induction of hepatomas secreting large amounts of alpha-fetoprotein.
作者信息
Smith C J, Kelleher P C
出版信息
Cancer Lett. 1977 Jul;3(1-2):53-7. doi: 10.1016/s0304-3835(77)94089-7.
PMID:70269
Abstract
Hepatomas secreting large amounts of alpha-fetoprotein were induced in Fischer rats by the continuous feeding of 0.06% 3'-methyl-4-dimethylaminoazobenzene. Serum alpha-fetoprotein concentrations in the 59 hepatoma-bearing rats ranged from 92--3260 microgram/ml (mean, 972 microgram/ml; median, 830 microgram/ml) at the time of primary tumor transplantation.
摘要
通过持续喂食0.06%的3'-甲基-4-二甲基氨基偶氮苯，在Fischer大鼠中诱导出分泌大量甲胎蛋白的肝癌。在原发性肿瘤移植时，59只荷肝癌大鼠的血清甲胎蛋白浓度范围为92 - 3260微克/毫升（平均972微克/毫升；中位数830微克/毫升）。
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