[Diabetogenic factor in the blood plasma in diabetes mellitus].

The blood plasma of rats with stable alloxan diabetes, injected three times in appropriate intravenous doses to intact rats, provoked in the rats-recipients hyperglycemia and hyperuricemia, persisted within 14 days. Under the same conditions the blood plasma of patients with diabetes mellitus induced hyperglycemia in the rats-recipients without hyperuricemia development during the same time period. A preliminary intravenous injection of heparin in a dose of 100 E (5 minutes before injecting the plasma of rats with alloxan diabetes or the plasma of patients with diabetes mellitus) completely prevented hyperglycemia and hyperuricemia development in the recipients. Intravenous injections of the blood plasma of healthy animals and humans did not provoke hyperglycemia and hyperuricemia arising in the rats-recipients. It is concluded, that in the blood plasma of animals with alloxan diabetes and in patients with diabetes mellitus the diabetogenic factor is present, being deactivated under heparin effect.