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[在德国进行的1%环吡酮胺聚乙二醇400溶液治疗皮肤真菌病的开放临床试验/缩短疗程的研究(作者译)]

[Open clinical trial in dermal mycoses of a 1% ciclopiroxolamine solution in polyethylene glycol 400 carried out in FR Germany/Study with shortened therapy (author's transl)].

作者信息

Torres J, Savopoulos C, Dittmar W

出版信息

Arzneimittelforschung. 1981;31(8A):1373-6.

PMID:7028049
Abstract

In an open multicentre study, a 1% solution of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic. Hoe 296, Batrafen) in polyethylene glycol 400 was examined for its topical activity in 344 cases of dermal mycoses. 65.4% of them were caused by dermatophytes and 19.2% by yeast-like fungi. In most cases, the treatment period was two weeks, with one or two daily applications. The examiners found global therapeutic effectiveness in 97.5% of the mycoses, the rate of very good and good results being 84.0%, and a very good tolerance in 99.0%. Individual side effects were predominantly subjective and transient.

摘要

在一项开放性多中心研究中,对344例皮肤真菌病患者使用聚乙二醇400中含1%的6-环己基-1-羟基-4-甲基-2(1H)-吡啶酮2-氨基乙醇盐(环吡酮胺,Cic. Hoe 296,Batrafen)溶液进行局部活性研究。其中65.4%由皮肤癣菌引起,19.2%由酵母样真菌引起。大多数情况下,治疗期为两周,每天用药一或两次。检查者发现97.5%的真菌病有总体治疗效果,极佳和良好效果率为84.0%,耐受性良好率为99.0%。个别副作用主要为主观性且短暂。

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