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[在德国进行的1%环吡酮胺聚乙二醇400溶液治疗皮肤真菌病的开放临床试验/缩短疗程的研究(作者译)]

[Open clinical trial in dermal mycoses of a 1% ciclopiroxolamine solution in polyethylene glycol 400 carried out in FR Germany/Study with shortened therapy (author's transl)].

作者信息

Torres J, Savopoulos C, Dittmar W

出版信息

Arzneimittelforschung. 1981;31(8A):1373-6.

PMID:7028049
Abstract

In an open multicentre study, a 1% solution of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic. Hoe 296, Batrafen) in polyethylene glycol 400 was examined for its topical activity in 344 cases of dermal mycoses. 65.4% of them were caused by dermatophytes and 19.2% by yeast-like fungi. In most cases, the treatment period was two weeks, with one or two daily applications. The examiners found global therapeutic effectiveness in 97.5% of the mycoses, the rate of very good and good results being 84.0%, and a very good tolerance in 99.0%. Individual side effects were predominantly subjective and transient.

摘要

在一项开放性多中心研究中,对344例皮肤真菌病患者使用聚乙二醇400中含1%的6-环己基-1-羟基-4-甲基-2(1H)-吡啶酮2-氨基乙醇盐(环吡酮胺,Cic. Hoe 296,Batrafen)溶液进行局部活性研究。其中65.4%由皮肤癣菌引起,19.2%由酵母样真菌引起。大多数情况下,治疗期为两周,每天用药一或两次。检查者发现97.5%的真菌病有总体治疗效果,极佳和良好效果率为84.0%,耐受性良好率为99.0%。个别副作用主要为主观性且短暂。

相似文献

1
[Open clinical trial in dermal mycoses of a 1% ciclopiroxolamine solution in polyethylene glycol 400 carried out in FR Germany/Study with shortened therapy (author's transl)].[在德国进行的1%环吡酮胺聚乙二醇400溶液治疗皮肤真菌病的开放临床试验/缩短疗程的研究(作者译)]
Arzneimittelforschung. 1981;31(8A):1373-6.
2
[Non-European open clinical studies on the efficacy and tolerance of ciclopiroxolamine in dermatomycoses (author's transl)].环吡酮胺治疗皮肤真菌病的非欧洲开放性临床疗效及耐受性研究(作者译)
Arzneimittelforschung. 1981;31(8A):1381-5.
3
[Clinical results with the antimycotic agent ciclopiroxolamine (author's transl)].
Arzneimittelforschung. 1981;31(8A):1360-5.
4
[Comparative double-blind study on ciclopiroxolamine cream and placebo cream in dermatophytoses (author's transl)].
Arzneimittelforschung. 1981;31(8A):1376-8.
5
[Selected double-blind comparative studies on the efficacy and tolerance of ciclopiroxolamine solution and cream].[关于环吡酮胺溶液和乳膏疗效及耐受性的双盲对照研究精选]
Arzneimittelforschung. 1981;31(8A):1378-81.
6
[Open clinical study on the efficacy and tolerance of ciclopiroxolamine in vulvovaginal candidosis (author's transl)].
Arzneimittelforschung. 1981;31(8A):1366-8.
7
[On the local efficacy of ciclopiroxolamine in onychomycoses (author's transl)].
Arzneimittelforschung. 1981;31(8A):1369-72.
8
[Microbiological laboratory studies with ciclopiroxolamine (author's transl)].[环吡酮胺的微生物学实验室研究(作者译)]
Arzneimittelforschung. 1981;31(8A):1317-22.
9
[Liberation of ciclopiroxolamine from dermatological preparations (author's transl)].从皮肤科制剂中释放出环吡酮胺(作者译)
Arzneimittelforschung. 1981;31(8A):1332-7.
10
[An open clinico-mycologic study on the efficiency and tolerability of ciclopiroxolamine].[环吡酮胺有效性及耐受性的开放性临床真菌学研究]
G Ital Dermatol Venereol. 1986 Mar-Apr;121(2):XXIX-XXXII.

引用本文的文献

1
Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent.环吡酮胺:作为一种局部抗真菌药物,其近期的非临床和临床数据。
Drugs. 2010 Nov 12;70(16):2133-52. doi: 10.2165/11538110-000000000-00000.
2
The dermatophytes.皮肤癣菌
Clin Microbiol Rev. 1995 Apr;8(2):240-59. doi: 10.1128/CMR.8.2.240.