Beyer M
Arzneimittelforschung. 1981;31(8A):1378-81.
The results of selected double-blind comparative studies, which had been conducted outside the Federal Republic of Germany, are reported on in summary. In these trials, a 1% solution of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen) was compared with a 1% solution of tolnaftate (2 studies) and clotrimazole (1 study), respectively, and a 1% Cic cream was compared with a 1% clotrimazole cream (2 studies). The three compounds showed a similar efficacy against the respective groups of sensitive organisms. Particular characteristics and advantages of Cic which were observed with other modes of administration in studies conducted later on, had not been the objective of the trials reported here.
以下是对在德意志联邦共和国境外进行的部分双盲对比研究结果的简要报告。在这些试验中，分别将6 - 环己基 - 1 - 羟基 - 4 - 甲基 - 2(1H)-吡啶酮2 - 氨基乙醇盐（环吡酮胺，Cic，Hoe 296，巴特芬）的1%溶液与托萘酯的1%溶液（2项研究）和克霉唑的1%溶液（1项研究）进行比较，并且将1%环吡酮胺乳膏与1%克霉唑乳膏进行比较（2项研究）。这三种化合物对各自的敏感生物体组显示出相似的疗效。环吡酮胺在后来进行的研究中通过其他给药方式观察到的特殊特性和优势，并非此处所报告试验的目标。
