Dittmar W
Arzneimittelforschung. 1981;31(8A):1381-5.
A survey is given of twenty published open clinical studies carried out outside Europe. They concern the topical action of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen) in 991 cases of skin disorders, mostly mycoses. 70.7% of the disorders were dermatophytoses, 18.9% candidoses. 6.1% pityriasis versicolor, and 4.2% other skin infections. Four trials were done with 1% Cic cream (o/w-type-emulsion) in 157 dermal disorders and 16 trials with 1% Cic solution (vehicle: polyethylene glycol 400) in 834 cases. Several selected studies are reported in detail, the other are parts of a summarizing survey. After a treatment period which, as a rule, was limited to 3 weeks, the global success rate was 96% (healing and distinct improvement). Any side effects were only seldom recorded.
对欧洲以外进行的20项已发表的开放性临床研究进行了综述。这些研究涉及6-环己基-1-羟基-4-甲基-2(1H)-吡啶酮2-氨基乙醇盐（环吡酮胺，Cic，Hoe 296，Batrafen）在991例皮肤疾病中的局部作用，这些疾病大多为真菌病。其中70.7%为皮肤癣菌病，18.9%为念珠菌病，6.1%为花斑癣，4.2%为其他皮肤感染。对157例皮肤疾病使用1%环吡酮胺乳膏（水包油型乳剂）进行了4项试验，对834例病例使用1%环吡酮胺溶液（赋形剂：聚乙二醇400）进行了16项试验。详细报告了几项选定的研究，其他研究则是总结性综述的一部分。在通常限于3周的治疗期后，总体成功率为96%（治愈和明显改善）。很少记录到任何副作用。
