Petri W
Arzneimittelforschung. 1981;31(8A):1332-7.
Using 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen) cream as an example, the method for measuring the in vitro liberation from some spreadable dermatological preparations of active substance with an antimycotic action is discussed. In addition, a description is given of a test model for measuring the spreading power of cream or ointment preparations. The tests also include for comparison purposes several antimycotic preparations at present on the market. The extent to which in vitro results of liberation of active substance combined with the results obtained on spreading power permit a prediction as to the penetration and permeation behaviour of an antimycotic preparation applied dermally is discussed.
以6-环己基-1-羟基-4-甲基-2(1H)-吡啶酮2-氨基乙醇盐（环吡酮胺，Cic，Hoe 296，Batrafen）乳膏为例，讨论了测定某些具有抗真菌作用的活性物质的可涂抹皮肤科制剂体外释放度的方法。此外，还介绍了一种用于测定乳膏或软膏制剂铺展力的测试模型。为作比较，测试还包括目前市场上的几种抗真菌制剂。讨论了活性物质体外释放结果与铺展力测试结果相结合在多大程度上能够预测经皮应用抗真菌制剂的渗透和透皮行为。
