慢性利尿治疗对原发性高血压患者血浆肾素-血管紧张素-醛固酮系统的影响。
Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension.
作者信息
Lijnen P, Fagard R, Staessen J, Amery A
出版信息
Br J Clin Pharmacol. 1981 Sep;12(3):387-92. doi: 10.1111/j.1365-2125.1981.tb01231.x.
Abstract
1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the maximum level reached after 1 week. 3 A significant (P less than 0.01) correlation (r = 0.74) between changes in plasma angiotensin II and renin activity provoked by chronic treatment for 3 months with hydrochlorothiazide and tienilic acid was found. 4 The increase in plasma aldosterone during chronic treatment with hydrochlorothiazide and tienilic acid (1000 mg) is related (r = 0.68; P less than 0.01) to the rise in plasma angiotensin II.
摘要
- 长期使用恒定剂量的氢氯噻嗪或替尼酸治疗会使血浆肾素活性（PRA）迅速升高，在第一周内达到最大值。2. 在长达1个月至1年的慢性利尿治疗期间，PRA保持在相当恒定的升高水平，尽管略低于1周后达到的最高水平。3. 发现使用氢氯噻嗪和替尼酸进行3个月的慢性治疗所引发的血浆血管紧张素II变化与肾素活性之间存在显著（P<0.01）相关性（r = 0.74）。4. 使用氢氯噻嗪和替尼酸（1000毫克）进行慢性治疗期间，血浆醛固酮的升高与血浆血管紧张素II的升高相关（r = 0.68；P<0.01）。
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本文引用的文献
1
Hemodynamic changes during long-term thiazide treatment of essential hypertension in responders and nonresponders.原发性高血压患者长期接受噻嗪类药物治疗时，反应者与无反应者的血流动力学变化。
Clin Pharmacol Ther. 1980 Mar;27(3):328-36. doi: 10.1038/clpt.1980.44.
2
3
Vasoconstriction-volume analysis for understanding and treating hypertension: the use of renin and aldosterone profiles.用于理解和治疗高血压的血管收缩-容量分析：肾素和醛固酮谱的应用
Am J Med. 1973 Sep;55(3):261-74. doi: 10.1016/0002-9343(73)90128-9.
4
Metabolism and blood levels of angiotensin II in normal subjects, renal disease, and essential hypertension.
Circ Res. 1970 Oct;27:Suppl 2:177+.
5
Renin-angiotensin-aldosterone system during chronic thiazide therapy of benign hypertension.良性高血压患者长期噻嗪类治疗期间的肾素-血管紧张素-醛固酮系统
Circulation. 1968 Jan;37(1):27-35. doi: 10.1161/01.cir.37.1.27.
6
Stimulated renin: a screening test for hypertension.刺激肾素：一种高血压筛查试验。
Ann Intern Med. 1975 Jan;82(1):27-34. doi: 10.7326/0003-4819-82-1-27.
7
Dissociation of blood angiotensin II and plasma renin activity during chronic treatment in essential hypertension.
Clin Sci Mol Med Suppl. 1976 Dec;3:201s-202s. doi: 10.1042/cs051201s.
8
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.血浆去甲肾上腺素、肾上腺素和多巴胺的同步单同位素放射酶法测定
Life Sci. 1977 Sep 1;21(5):625-36. doi: 10.1016/0024-3205(77)90070-4.
9
Direct radioimmunoassay of plasma aldosterone in normal subjects.
Clin Chim Acta. 1978 Mar 15;84(3):305-14. doi: 10.1016/0009-8981(78)90246-2.
10
Faster radioimmunoassay of angiotensin I at 37 degrees C.37摄氏度下血管紧张素I的快速放射免疫测定法。
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