Insel T R, Siever L J
J Clin Psychopharmacol. 1981 Jul;1(4):207-13. doi: 10.1097/00004714-198107000-00005.
The authors review studies of dopaminergic agents in affective disorder patients. Although evidence from cerebrospinal fluid studies, from the pharmacology of the antidepressants, and from several clinical trials implicates the dopamine system in the regulation of mood or activity level, as yet, no replicated study shows that affective level disorder patients are different from normals and their neuroendocrine response to the dopaminergic agents L-dopa and apomorphine. Some possible reasons for this apparent normality of neuroendocrine response are discussed.
作者们回顾了关于情感障碍患者中多巴胺能药物的研究。尽管来自脑脊液研究、抗抑郁药药理学以及多项临床试验的证据表明多巴胺系统参与了情绪或活动水平的调节，但到目前为止，尚无重复性研究表明情感障碍患者与正常人不同，以及他们对多巴胺能药物左旋多巴和阿扑吗啡的神经内分泌反应存在差异。文中讨论了神经内分泌反应呈现这种明显正常状态的一些可能原因。
